Raloxifene attenuates oxidative stress and preserves mitochondrial function in astrocytic cells upon glucose deprivation

Diego J. Vesga-Jiménez, Oscar Hidalgo-Lanussa, Eliana Baez-Jurado, Valentina Echeverria, Ghulam Md Ashraf, Amirhossein Sahebkar, George E. Barreto

Research output: Contribution to journalArticlepeer-review

Abstract

Oxidative stress and mitochondrial dysfunction induced by metabolic insults are both hallmarks of various neurological disorders, whereby neuronal cells are severely affected by decreased glucose supply to the brain. Likely injured, astrocytes are important for neuronal homeostasis and therapeutic strategies should be directed towards improving astrocytic functions to improve brain's outcome. In the present study, we aimed to assess the actions of raloxifene, a selective estrogen receptor modulator in astrocytic cells under glucose deprivation. Our findings indicated that pretreatment with 1 µM raloxifene results in an increase in cell viability and attenuated nuclei fragmentation. Raloxifene's actions also rely on the reduction of oxidative stress and preservation of mitochondrial function in glucose-deprived astrocytic cells, suggesting the possible direct effects of this compound on mitochondria. In conclusion, our results demonstrate that raloxifene's protective actions might be mediated in part by astrocytes in the setting of a metabolic insult.

Original languageEnglish
Pages (from-to)2051-2057
Number of pages7
JournalJournal of Cellular Physiology
Volume234
Issue number3
DOIs
Publication statusPublished - Mar 2019
Externally publishedYes

Keywords

  • astrocytes
  • glucose deprivation
  • mitochondria
  • neuroprotection
  • raloxifene

Fingerprint

Dive into the research topics of 'Raloxifene attenuates oxidative stress and preserves mitochondrial function in astrocytic cells upon glucose deprivation'. Together they form a unique fingerprint.

Cite this