Recent advances in understanding FOXN3 in breast cancer, and other malignancies

Xiangyi Kong; Jie Zhai; Chengrui Yan; Yan Song; Jing Wang; Xiaofeng Bai; James A.L. Brown; Yi Fang

doi:10.3389/fonc.2019.00234

Recent advances in understanding FOXN3 in breast cancer, and other malignancies

Xiangyi Kong, Jie Zhai, Chengrui Yan, Yan Song, Jing Wang, Xiaofeng Bai, James A.L. Brown, Yi Fang

Research output: Contribution to journal › Review article › peer-review

Abstract

FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. While the roles of FOXN3 role in some cancers have been explored, its role in breast cancer remains unclear. Here we describe current state of knowledge of FOXN3 functions, and focus on its roles (known and potential) in breast cancer.

Original language	English
Article number	234
Pages (from-to)	234
Journal	Frontiers in Oncology
Volume	9
Issue number	MAY
DOIs	https://doi.org/10.3389/fonc.2019.00234
Publication status	Published - 2019
Externally published	Yes

Keywords

Breast
Cancer
Forkhead
FOXN3
Function
Malignancy
Regulation
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fonc.2019.00234

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title = "Recent advances in understanding FOXN3 in breast cancer, and other malignancies",

abstract = "FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. While the roles of FOXN3 role in some cancers have been explored, its role in breast cancer remains unclear. Here we describe current state of knowledge of FOXN3 functions, and focus on its roles (known and potential) in breast cancer.",

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author = "Xiangyi Kong and Jie Zhai and Chengrui Yan and Yan Song and Jing Wang and Xiaofeng Bai and Brown, {James A.L.} and Yi Fang",

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doi = "10.3389/fonc.2019.00234",

language = "English",

volume = "9",

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journal = "Frontiers in Oncology",

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T1 - Recent advances in understanding FOXN3 in breast cancer, and other malignancies

AU - Kong, Xiangyi

AU - Zhai, Jie

AU - Yan, Chengrui

AU - Song, Yan

AU - Wang, Jing

AU - Bai, Xiaofeng

AU - Brown, James A.L.

AU - Fang, Yi

PY - 2019

Y1 - 2019

N2 - FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. While the roles of FOXN3 role in some cancers have been explored, its role in breast cancer remains unclear. Here we describe current state of knowledge of FOXN3 functions, and focus on its roles (known and potential) in breast cancer.

AB - FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. While the roles of FOXN3 role in some cancers have been explored, its role in breast cancer remains unclear. Here we describe current state of knowledge of FOXN3 functions, and focus on its roles (known and potential) in breast cancer.

KW - Breast

KW - Cancer

KW - Forkhead

KW - FOXN3

KW - Function

KW - Malignancy

KW - Regulation

KW - Review

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DO - 10.3389/fonc.2019.00234

M3 - Review article

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SN - 2234-943X

VL - 9

SP - 234

JO - Frontiers in Oncology

JF - Frontiers in Oncology

IS - MAY

M1 - 234

ER -

Recent advances in understanding FOXN3 in breast cancer, and other malignancies

Abstract

Keywords

UN SDGs

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