TY - JOUR
T1 - Remote history of VTE is associated with severe COVID-19 in middle and older age
T2 - UK Biobank cohort study
AU - Anderson, Jana J.
AU - Ho, Frederick K.
AU - Niedzwiedz, Claire L.
AU - Katikireddi, Srinivasa Vittal
AU - Celis-Morales, Carlos
AU - Iliodromiti, Stamatina
AU - Welsh, Paul
AU - Pellicori, Pierpaolo
AU - Demou, Evangelia
AU - Hastie, Claire E.
AU - Lyall, Donald M.
AU - Gray, Stuart R.
AU - Forbes, John F.
AU - Gill, Jason M.R.
AU - Mackay, Daniel F.
AU - Berry, Colin
AU - Cleland, John G.F.
AU - Sattar, Naveed
AU - Pell, Jill P.
N1 - Publisher Copyright:
© 2021 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis.
PY - 2021/10
Y1 - 2021/10
N2 - Background: Venous thromboembolism (VTE) is a common, life-threatening complication of COVID-19 infection. COVID-19 risk-prediction models include a history of VTE. However, it is unclear whether remote history (>9 years previously) of VTE also confers increased risk of COVID-19. Objectives: To investigate possible association between VTE and COVID-19 severity, independent of other risk factors. Methods: Cohort study of UK Biobank participants recruited between 2006 and 2010. Baseline data, including history of VTE, were linked to COVID-19 test results, COVID-19-related hospital admissions, and COVID-19 deaths. The risk of COVID-19 hospitalization or death was compared for participants with a remote history VTE versus without. Poisson regression models were run univariately then adjusted stepwise for sociodemographic, lifestyle, and comorbid covariates. Results: After adjustment for sociodemographic and lifestyle confounders and comorbid conditions, remote history of VTE was associated with nonfatal community (RR 1.61, 95% CI 1.02–2.54, p =.039), nonfatal hospitalized (RR 1.52, 95% CI 1.06–2.17, p =.024) and severe (hospitalized or fatal) (RR 1.40, 95% CI 1.04–1.89, p =.025) COVID-19. Associations with remote history of VTE were stronger among men (severe COVID-19: RR 1.68, 95% CI 1.14–2.42, p =.009) than for women (severe COVID-19: RR 1.07, 95% CI 0.66–1.74, p =.786). Conclusion: Our findings support inclusion of remote history of VTE in COVID-19 risk-prediction scores, and consideration of sex-specific risk scores.
AB - Background: Venous thromboembolism (VTE) is a common, life-threatening complication of COVID-19 infection. COVID-19 risk-prediction models include a history of VTE. However, it is unclear whether remote history (>9 years previously) of VTE also confers increased risk of COVID-19. Objectives: To investigate possible association between VTE and COVID-19 severity, independent of other risk factors. Methods: Cohort study of UK Biobank participants recruited between 2006 and 2010. Baseline data, including history of VTE, were linked to COVID-19 test results, COVID-19-related hospital admissions, and COVID-19 deaths. The risk of COVID-19 hospitalization or death was compared for participants with a remote history VTE versus without. Poisson regression models were run univariately then adjusted stepwise for sociodemographic, lifestyle, and comorbid covariates. Results: After adjustment for sociodemographic and lifestyle confounders and comorbid conditions, remote history of VTE was associated with nonfatal community (RR 1.61, 95% CI 1.02–2.54, p =.039), nonfatal hospitalized (RR 1.52, 95% CI 1.06–2.17, p =.024) and severe (hospitalized or fatal) (RR 1.40, 95% CI 1.04–1.89, p =.025) COVID-19. Associations with remote history of VTE were stronger among men (severe COVID-19: RR 1.68, 95% CI 1.14–2.42, p =.009) than for women (severe COVID-19: RR 1.07, 95% CI 0.66–1.74, p =.786). Conclusion: Our findings support inclusion of remote history of VTE in COVID-19 risk-prediction scores, and consideration of sex-specific risk scores.
KW - COVID-19 severity
KW - DVT
KW - PE
KW - SARS-CoV2 infection
KW - venous thromboembolism
UR - http://www.scopus.com/inward/record.url?scp=85111880701&partnerID=8YFLogxK
U2 - 10.1111/jth.15452
DO - 10.1111/jth.15452
M3 - Article
C2 - 34242477
AN - SCOPUS:85111880701
SN - 1538-7933
VL - 19
SP - 2533
EP - 2538
JO - Journal of Thrombosis and Haemostasis
JF - Journal of Thrombosis and Haemostasis
IS - 10
ER -