TY - JOUR
T1 - Response surface optimization of phenolic compounds from jabuticaba (Myrciaria cauliflora [Mart.] O.Berg) seeds
T2 - Antioxidant, antimicrobial, antihyperglycemic, antihypertensive and cytotoxic assessments
AU - Fidelis, Marina
AU - Vieira do Carmo, Mariana Araújo
AU - Azevedo, Luciana
AU - Cruz, Thiago Mendanha
AU - Marques, Mariza Boscacci
AU - Myoda, Takao
AU - Sant'Ana, Anderson S.
AU - Furtado, Marianna Miranda
AU - Wen, Mingchun
AU - Zhang, Liang
AU - Rosso, Neiva Deliberali
AU - Genovese, Maria Inês
AU - Oh, Won Young
AU - Shahidi, Fereidoon
AU - Pap, Nora
AU - Granato, Daniel
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/8
Y1 - 2020/8
N2 - The aim of this study was to evaluate the effects of different solvents and maximize the extraction of bioactive compounds from jabuticaba (Myrciaria cauliflora) seeds. In general, the solvent system composed of water and propanone (52:48 v/v) modified the extract polarity and increased extraction yield of bioactive compounds. The optimized extract presented antioxidant capacity measured by different chemical and biological assays. The optimized extract exerted antiproliferative and cytotoxic effects against A549 and HCT8 cells, antimicrobial and antihemolytic effects, inhibited α-amylase/α-glucosidase activities and presented in vitro antihypertensive effect. Nonetheless, the optimized extract showed no cytotoxicity in a human cell model (IMR90). Vescalagin, castalagin and ellagic acid were the major phenolic compounds in the optimized extract. Our results show that jabuticaba seed may be a potential ingredient for the development of potentially functional foods.
AB - The aim of this study was to evaluate the effects of different solvents and maximize the extraction of bioactive compounds from jabuticaba (Myrciaria cauliflora) seeds. In general, the solvent system composed of water and propanone (52:48 v/v) modified the extract polarity and increased extraction yield of bioactive compounds. The optimized extract presented antioxidant capacity measured by different chemical and biological assays. The optimized extract exerted antiproliferative and cytotoxic effects against A549 and HCT8 cells, antimicrobial and antihemolytic effects, inhibited α-amylase/α-glucosidase activities and presented in vitro antihypertensive effect. Nonetheless, the optimized extract showed no cytotoxicity in a human cell model (IMR90). Vescalagin, castalagin and ellagic acid were the major phenolic compounds in the optimized extract. Our results show that jabuticaba seed may be a potential ingredient for the development of potentially functional foods.
KW - Bioactivity
KW - Ellagitannins
KW - Functional foods
KW - Natural resources
KW - Response surface methodology
UR - http://www.scopus.com/inward/record.url?scp=85085568077&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2020.111439
DO - 10.1016/j.fct.2020.111439
M3 - Article
C2 - 32450285
AN - SCOPUS:85085568077
SN - 0278-6915
VL - 142
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
M1 - 111439
ER -