Response surface optimization of phenolic compounds from jabuticaba (Myrciaria cauliflora [Mart.] O.Berg) seeds: Antioxidant, antimicrobial, antihyperglycemic, antihypertensive and cytotoxic assessments

Marina Fidelis, Mariana Araújo Vieira do Carmo, Luciana Azevedo, Thiago Mendanha Cruz, Mariza Boscacci Marques, Takao Myoda, Anderson S. Sant'Ana, Marianna Miranda Furtado, Mingchun Wen, Liang Zhang, Neiva Deliberali Rosso, Maria Inês Genovese, Won Young Oh, Fereidoon Shahidi, Nora Pap, Daniel Granato

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to evaluate the effects of different solvents and maximize the extraction of bioactive compounds from jabuticaba (Myrciaria cauliflora) seeds. In general, the solvent system composed of water and propanone (52:48 v/v) modified the extract polarity and increased extraction yield of bioactive compounds. The optimized extract presented antioxidant capacity measured by different chemical and biological assays. The optimized extract exerted antiproliferative and cytotoxic effects against A549 and HCT8 cells, antimicrobial and antihemolytic effects, inhibited α-amylase/α-glucosidase activities and presented in vitro antihypertensive effect. Nonetheless, the optimized extract showed no cytotoxicity in a human cell model (IMR90). Vescalagin, castalagin and ellagic acid were the major phenolic compounds in the optimized extract. Our results show that jabuticaba seed may be a potential ingredient for the development of potentially functional foods.

Original languageEnglish
Article number111439
JournalFood and Chemical Toxicology
Volume142
DOIs
Publication statusPublished - Aug 2020
Externally publishedYes

Keywords

  • Bioactivity
  • Ellagitannins
  • Functional foods
  • Natural resources
  • Response surface methodology

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