Role of Astrocytes in Major Neuropsychiatric Disorders

Xiaolu Zhang; Rawan S Alnafisah; Abdul-Rizaq A Hamoud; Rammohan Shukla; Zhexing Wen; Robert E McCullumsmith; Sinead M O'Donovan

doi:10.1007/s11064-020-03212-x

Role of Astrocytes in Major Neuropsychiatric Disorders

Xiaolu Zhang, Rawan S Alnafisah, Abdul-Rizaq A Hamoud, Rammohan Shukla, Zhexing Wen, Robert E McCullumsmith, Sinead M O'Donovan

Research output: Contribution to journal › Review article › peer-review

Abstract

Astrocytes are the primary homeostatic cells of the central nervous system, essential for normal neuronal development and function, metabolism and response to injury and inflammation. Here, we review postmortem studies examining changes in astrocytes in subjects diagnosed with the neuropsychiatric disorders schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BPD). We discuss the astrocyte-related changes described in the brain in these disorders and the potential effects of psychotropic medication on these findings. Finally, we describe emerging tools that can be used to study the role of astrocytes in neuropsychiatric illness.

Original language	English
Pages (from-to)	2715-2730
Number of pages	16
Journal	Neurochemical Research
Volume	46
Issue number	10
DOIs	https://doi.org/10.1007/s11064-020-03212-x
Publication status	Published - Oct 2021
Externally published	Yes

Keywords

Animals
Antidepressive Agents/adverse effects
Antipsychotic Agents/adverse effects
Astrocytes/drug effects
Biomarkers/metabolism
Bipolar Disorder/metabolism
Brain/metabolism
Cell Count
Depressive Disorder, Major/metabolism
Humans
Schizophrenia/metabolism

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10.1007/s11064-020-03212-x

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title = "Role of Astrocytes in Major Neuropsychiatric Disorders",

abstract = "Astrocytes are the primary homeostatic cells of the central nervous system, essential for normal neuronal development and function, metabolism and response to injury and inflammation. Here, we review postmortem studies examining changes in astrocytes in subjects diagnosed with the neuropsychiatric disorders schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BPD). We discuss the astrocyte-related changes described in the brain in these disorders and the potential effects of psychotropic medication on these findings. Finally, we describe emerging tools that can be used to study the role of astrocytes in neuropsychiatric illness.",

keywords = "Animals, Antidepressive Agents/adverse effects, Antipsychotic Agents/adverse effects, Astrocytes/drug effects, Biomarkers/metabolism, Bipolar Disorder/metabolism, Brain/metabolism, Cell Count, Depressive Disorder, Major/metabolism, Humans, Schizophrenia/metabolism",

author = "Xiaolu Zhang and Alnafisah, {Rawan S} and Hamoud, {Abdul-Rizaq A} and Rammohan Shukla and Zhexing Wen and McCullumsmith, {Robert E} and O'Donovan, {Sinead M}",

note = "{\textcopyright} 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.",

year = "2021",

month = oct,

doi = "10.1007/s11064-020-03212-x",

language = "English",

volume = "46",

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journal = "Neurochemical Research",

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T1 - Role of Astrocytes in Major Neuropsychiatric Disorders

AU - Zhang, Xiaolu

AU - Alnafisah, Rawan S

AU - Hamoud, Abdul-Rizaq A

AU - Shukla, Rammohan

AU - Wen, Zhexing

AU - McCullumsmith, Robert E

AU - O'Donovan, Sinead M

PY - 2021/10

Y1 - 2021/10

N2 - Astrocytes are the primary homeostatic cells of the central nervous system, essential for normal neuronal development and function, metabolism and response to injury and inflammation. Here, we review postmortem studies examining changes in astrocytes in subjects diagnosed with the neuropsychiatric disorders schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BPD). We discuss the astrocyte-related changes described in the brain in these disorders and the potential effects of psychotropic medication on these findings. Finally, we describe emerging tools that can be used to study the role of astrocytes in neuropsychiatric illness.

AB - Astrocytes are the primary homeostatic cells of the central nervous system, essential for normal neuronal development and function, metabolism and response to injury and inflammation. Here, we review postmortem studies examining changes in astrocytes in subjects diagnosed with the neuropsychiatric disorders schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BPD). We discuss the astrocyte-related changes described in the brain in these disorders and the potential effects of psychotropic medication on these findings. Finally, we describe emerging tools that can be used to study the role of astrocytes in neuropsychiatric illness.

KW - Animals

KW - Antidepressive Agents/adverse effects

KW - Antipsychotic Agents/adverse effects

KW - Astrocytes/drug effects

KW - Biomarkers/metabolism

KW - Bipolar Disorder/metabolism

KW - Brain/metabolism

KW - Cell Count

KW - Depressive Disorder, Major/metabolism

KW - Humans

KW - Schizophrenia/metabolism

U2 - 10.1007/s11064-020-03212-x

DO - 10.1007/s11064-020-03212-x

M3 - Review article

C2 - 33411227

SN - 0364-3190

VL - 46

SP - 2715

EP - 2730

JO - Neurochemical Research

JF - Neurochemical Research

IS - 10

ER -

Role of Astrocytes in Major Neuropsychiatric Disorders

Abstract

Keywords

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