TY - JOUR
T1 - Role of Exosomes in Epithelial-Mesenchymal Transition
AU - Bhattacharya, Bikramjit
AU - Nag, Sagnik
AU - Mukherjee, Sayantanee
AU - Kulkarni, Mrunal
AU - Chandane, Priti
AU - Mandal, Debashmita
AU - Mukerjee, Nobendu
AU - Mirgh, Divya
AU - Anand, Krishnan
AU - Adhikari, Manab Deb
AU - Gorai, Sukhamoy
AU - Thorat, Nanasaheb
N1 - Publisher Copyright:
© 2023 The Authors. Published by American Chemical Society.
PY - 2024/1/15
Y1 - 2024/1/15
N2 - Epithelial-mesenchymal transition (EMT) is a fundamental process driving cancer metastasis, transforming non-motile cells into a motile population that migrates to distant organs and forms secondary tumors. In recent years, cancer research has revealed a strong connection between exosomes and the EMT. Exosomes, a subpopulation of extracellular vesicles, facilitate cellular communication and dynamically regulate various aspects of cancer metastasis, including immune cell suppression, extracellular matrix remodeling, metastasis initiation, EMT initiation, and organ-specific metastasis. Tumor-derived exosomes (TEXs) and their molecular cargo, comprising proteins, lipids, nucleic acids, and carbohydrates, are essential components that promote EMT in cancer. TEXs miRNAs play a crucial role in reprogramming the tumor microenvironment, while TEX surface integrins contribute to organ-specific metastasis. Exosome-based cancer metastasis research offers a deeper understanding about cancer and an effective theranostic platform development. Additionally, various therapeutic sources of exosomes are paving the way for innovative cancer treatment development. In this Review, we spotlight the role of exosomes in EMT and their theranostic impact, aiming to inspire cancer researchers worldwide to explore this fascinating field in more innovative ways.
AB - Epithelial-mesenchymal transition (EMT) is a fundamental process driving cancer metastasis, transforming non-motile cells into a motile population that migrates to distant organs and forms secondary tumors. In recent years, cancer research has revealed a strong connection between exosomes and the EMT. Exosomes, a subpopulation of extracellular vesicles, facilitate cellular communication and dynamically regulate various aspects of cancer metastasis, including immune cell suppression, extracellular matrix remodeling, metastasis initiation, EMT initiation, and organ-specific metastasis. Tumor-derived exosomes (TEXs) and their molecular cargo, comprising proteins, lipids, nucleic acids, and carbohydrates, are essential components that promote EMT in cancer. TEXs miRNAs play a crucial role in reprogramming the tumor microenvironment, while TEX surface integrins contribute to organ-specific metastasis. Exosome-based cancer metastasis research offers a deeper understanding about cancer and an effective theranostic platform development. Additionally, various therapeutic sources of exosomes are paving the way for innovative cancer treatment development. In this Review, we spotlight the role of exosomes in EMT and their theranostic impact, aiming to inspire cancer researchers worldwide to explore this fascinating field in more innovative ways.
KW - Biomarkers
KW - Cancer
KW - EMT
KW - Exosome
KW - Metastasis
KW - Therapeutic
UR - http://www.scopus.com/inward/record.url?scp=85181087783&partnerID=8YFLogxK
U2 - 10.1021/acsabm.3c00941
DO - 10.1021/acsabm.3c00941
M3 - Review article
C2 - 38108852
AN - SCOPUS:85181087783
SN - 2576-6422
VL - 7
SP - 44
EP - 58
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
IS - 1
ER -
