Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer’s Disease and CNS-Related Disorders

Athanasios Alexiou, Georgia Soursou, Stylianos Chatzichronis, Ermis Gasparatos, Mohammad Amjad Kamal, Nagendra Sastry Yarla, Asma Perveen, George E. Barreto, Ghulam Md Ashraf

Research output: Contribution to journalReview articlepeer-review

Abstract

Data obtained from several studies have shown that mitochondria are involved and play a central role in the progression of several distinct pathological conditions. Morphological alterations and disruptions on the functionality of mitochondria may be related to metabolic and energy deficiency in neurons in a neurodegenerative disorder. Several recent studies demonstrate the linkage between neurodegeneration and mitochondrial dynamics in the spectrum of a promising era called precision mitochondrial medicine. In this review paper, an analysis of the correlation between mitochondria, Alzheimer’s disease, and other central nervous system (CNS)-related disorders like the Parkinson’s disease and the autism spectrum disorder is under discussion. The role of GTPases like the mfn1, mfn2, opa1, and dlp1 in mitochondrial fission and fusion is also under investigation, influencing mitochondrial population and leading to oxidative stress and neuronal damage.

Original languageEnglish
Pages (from-to)4530-4538
Number of pages9
JournalMolecular Neurobiology
Volume56
Issue number6
DOIs
Publication statusPublished - 1 Jun 2019
Externally publishedYes

Keywords

  • Alzheimer’s disease
  • Mitochondria
  • Mitochondrial dynamics
  • Neurodegenerative diseases
  • Oxidative stress
  • Parkinson’s disease

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