Role of neuroglobin in the neuroprotective actions of estradiol and estrogenic compounds

George E. Barreto, Andrew J. McGovern, Luis M. Garcia-Segura

Research output: Contribution to journalReview articlepeer-review

Abstract

Estradiol exerts neuroprotective actions that are mediated by the regulation of a variety of signaling pathways and homeostatic molecules. Among these is neuroglobin, which is upregulated by estradiol and translocated to the mitochondria to sustain neuronal and glial cell adaptation to injury. In this paper, we will discuss the role of neuroglobin in the neuroprotective mechanisms elicited by estradiol acting on neurons, astrocytes and microglia. We will also consider the role of neuroglobin in the neuroprotective actions of clinically relevant synthetic steroids, such as tibolone. Finally, the possible contribution of the estrogenic regulation of neuroglobin to the generation of sex differences in brain pathology and the potential application of neuroglobin as therapy against neurological diseases will be examined.

Original languageEnglish
Article number1907
JournalCells
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 2021

Keywords

  • Astrocytes
  • Estrogen receptors
  • Microglia
  • Mitochondria
  • Neuron
  • Sex differences
  • Tibolone

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