TY - JOUR
T1 - Role of neuroinflammation and sex hormones in war-related PTSD
AU - Mendoza, Cristhian
AU - Barreto, George E.
AU - Ávila-Rodriguez, Marco
AU - Echeverria, Valentina
N1 - Publisher Copyright:
© 2016
PY - 2016/10/15
Y1 - 2016/10/15
N2 - The susceptibility to develop posttraumatic stress disorder (PTSD) is greatly influenced by both innate and environmental risk factors. One of these factors is gender, with women showing higher incidence of trauma-related mental health disorders than their male counterparts. The evidence so far links these differences in susceptibility or resilience to trauma to the neuroprotective actions of sex hormones in reducing neuroinflammation after severe stress exposure. In this review, we discuss the impact of war-related trauma on the incidence of PTSD in civilian and military populations as well as differences associated to gender in the incidence and recovery from PTSD. In addition, the mutually influencing role of inflammation, genetic, and sex hormones in modulating the consequences derived from exposure to traumatic events are discussed in light of current evidence.
AB - The susceptibility to develop posttraumatic stress disorder (PTSD) is greatly influenced by both innate and environmental risk factors. One of these factors is gender, with women showing higher incidence of trauma-related mental health disorders than their male counterparts. The evidence so far links these differences in susceptibility or resilience to trauma to the neuroprotective actions of sex hormones in reducing neuroinflammation after severe stress exposure. In this review, we discuss the impact of war-related trauma on the incidence of PTSD in civilian and military populations as well as differences associated to gender in the incidence and recovery from PTSD. In addition, the mutually influencing role of inflammation, genetic, and sex hormones in modulating the consequences derived from exposure to traumatic events are discussed in light of current evidence.
KW - Combat PTSD
KW - Fear
KW - Neuroinflammation
KW - Sex hormones
KW - Stress
KW - Trauma
UR - http://www.scopus.com/inward/record.url?scp=84970027608&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2016.05.016
DO - 10.1016/j.mce.2016.05.016
M3 - Review article
C2 - 27216917
AN - SCOPUS:84970027608
SN - 0303-7207
VL - 434
SP - 266
EP - 277
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
ER -