Role of proteases in the development and diseases of the lens

Research output: Contribution to journalArticlepeer-review

Abstract

Proteases have important roles in development and in disease. Here, the recent literature pertaining to the role of proteases in lens development (including lens fiber cell organelle loss) and cataract progression is reviewed. Families of proteases reviewed include caspases, calpains, cathepsins, the ubiquitin proteasome pathway and matrix metalloproteases. Proteases are also considered as potential targets for the pharmaceutical treatment for cataract and complications of cataract surgery, such as posterior capsule opacification. The development and use of such drugs is dependent upon gaining further insights into the roles of proteases in lens development, maturation, aging and cataract. Fruitful avenues for future research in this area are also identified.

Original languageEnglish
Pages (from-to)833-844
Number of pages12
JournalExpert Review of Ophthalmology
Volume2
Issue number5
DOIs
Publication statusPublished - 1 Oct 2007
Externally publishedYes

Keywords

  • calpain
  • caspase
  • cataract
  • cathepsin
  • development
  • lens
  • matrix metalloprotease
  • organelle loss
  • posterior capsule opacification
  • protease
  • proteasome

Fingerprint

Dive into the research topics of 'Role of proteases in the development and diseases of the lens'. Together they form a unique fingerprint.

Cite this