RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer

Padraic Flavin; Aisling Redmond; Jean McBryan; Sinead Cocchiglia; Paul Tibbitts; Patrick Fahy-Browne; Elaine Kay; Achim Treumann; Kilian Perrem; Marie McIlroy; Arnold D.K. Hill; Leonie S. Young

doi:10.1016/j.febslet.2011.07.005

RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer

Padraic Flavin, Aisling Redmond, Jean McBryan, Sinead Cocchiglia, Paul Tibbitts, Patrick Fahy-Browne, Elaine Kay, Achim Treumann, Kilian Perrem, Marie McIlroy, Arnold D.K. Hill, Leonie S. Young

Royal College of Surgeons in Ireland

Research output: Contribution to journal › Article › peer-review

Abstract

Human cancers utilise telomerase to maintain telomeres and prohibit cell senescence. Human telomerase reverse transcriptase (hTERT), an essential component of this complex, is regulated at the level of gene transcription. Using SILAC-proteomic analysis and molecular studies, we identified the AAA+ ATPase, RuvBl2 as a transcriptional regulator of hTERT and established that this regulation is through cooperation with Ets-2. In colon cancer patients, nuclear expression of RuvBl2 associated with nuclear expression of hTERT, pEts2 and advanced nodal disease (P < 0.01, P = 0.05 and P = 0.03 respectively, n = 170). These data firmly implicate RuvBl2 in Ets2 mediated regulation of hTERT in colon cancer which has functional and clinical consequences.

Original language	English
Pages (from-to)	2537-2544
Number of pages	8
Journal	FEBS Letters
Volume	585
Issue number	15
DOIs	https://doi.org/10.1016/j.febslet.2011.07.005
Publication status	Published - 4 Aug 2011
Externally published	Yes

Keywords

c-Myc
Colon cancer
hTERT
RuvBl2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.febslet.2011.07.005

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title = "RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer",

abstract = "Human cancers utilise telomerase to maintain telomeres and prohibit cell senescence. Human telomerase reverse transcriptase (hTERT), an essential component of this complex, is regulated at the level of gene transcription. Using SILAC-proteomic analysis and molecular studies, we identified the AAA+ ATPase, RuvBl2 as a transcriptional regulator of hTERT and established that this regulation is through cooperation with Ets-2. In colon cancer patients, nuclear expression of RuvBl2 associated with nuclear expression of hTERT, pEts2 and advanced nodal disease (P < 0.01, P = 0.05 and P = 0.03 respectively, n = 170). These data firmly implicate RuvBl2 in Ets2 mediated regulation of hTERT in colon cancer which has functional and clinical consequences.",

keywords = "c-Myc, Colon cancer, hTERT, RuvBl2",

author = "Padraic Flavin and Aisling Redmond and Jean McBryan and Sinead Cocchiglia and Paul Tibbitts and Patrick Fahy-Browne and Elaine Kay and Achim Treumann and Kilian Perrem and Marie McIlroy and Hill, {Arnold D.K.} and Young, {Leonie S.}",

year = "2011",

month = aug,

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doi = "10.1016/j.febslet.2011.07.005",

language = "English",

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T1 - RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer

AU - Flavin, Padraic

AU - Redmond, Aisling

AU - McBryan, Jean

AU - Cocchiglia, Sinead

AU - Tibbitts, Paul

AU - Fahy-Browne, Patrick

AU - Kay, Elaine

AU - Treumann, Achim

AU - Perrem, Kilian

AU - McIlroy, Marie

AU - Hill, Arnold D.K.

AU - Young, Leonie S.

PY - 2011/8/4

Y1 - 2011/8/4

N2 - Human cancers utilise telomerase to maintain telomeres and prohibit cell senescence. Human telomerase reverse transcriptase (hTERT), an essential component of this complex, is regulated at the level of gene transcription. Using SILAC-proteomic analysis and molecular studies, we identified the AAA+ ATPase, RuvBl2 as a transcriptional regulator of hTERT and established that this regulation is through cooperation with Ets-2. In colon cancer patients, nuclear expression of RuvBl2 associated with nuclear expression of hTERT, pEts2 and advanced nodal disease (P < 0.01, P = 0.05 and P = 0.03 respectively, n = 170). These data firmly implicate RuvBl2 in Ets2 mediated regulation of hTERT in colon cancer which has functional and clinical consequences.

AB - Human cancers utilise telomerase to maintain telomeres and prohibit cell senescence. Human telomerase reverse transcriptase (hTERT), an essential component of this complex, is regulated at the level of gene transcription. Using SILAC-proteomic analysis and molecular studies, we identified the AAA+ ATPase, RuvBl2 as a transcriptional regulator of hTERT and established that this regulation is through cooperation with Ets-2. In colon cancer patients, nuclear expression of RuvBl2 associated with nuclear expression of hTERT, pEts2 and advanced nodal disease (P < 0.01, P = 0.05 and P = 0.03 respectively, n = 170). These data firmly implicate RuvBl2 in Ets2 mediated regulation of hTERT in colon cancer which has functional and clinical consequences.

KW - c-Myc

KW - Colon cancer

KW - hTERT

KW - RuvBl2

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U2 - 10.1016/j.febslet.2011.07.005

DO - 10.1016/j.febslet.2011.07.005

M3 - Article

C2 - 21763315

AN - SCOPUS:79960907716

SN - 0014-5793

VL - 585

SP - 2537

EP - 2544

JO - FEBS Letters

JF - FEBS Letters

IS - 15

ER -

RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer

Abstract

Keywords

UN SDGs

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