SARS-CoV-2 Tests: Bridging the Gap between Laboratory Sensors and Clinical Applications

Nikita Toropov; Eleanor Osborne; Lovleen Tina Joshi; James Davidson; Caitlin Morgan; Joseph Page; Justin Pepperell; Frank Vollmer

doi:10.1021/acssensors.1c00612

SARS-CoV-2 Tests: Bridging the Gap between Laboratory Sensors and Clinical Applications

Nikita Toropov
, Eleanor Osborne
, Lovleen Tina Joshi
, James Davidson
, Caitlin Morgan
, Joseph Page
, Justin Pepperell
, Frank Vollmer

University of Exeter
University of Plymouth
Somerset NHS Foundation Trust

Research output: Contribution to journal › Review article › peer-review

Abstract

This review covers emerging biosensors for SARS-CoV-2 detection together with a review of the biochemical and clinical assays that are in use in hospitals and clinical laboratories. We discuss the gap in bridging the current practice of testing laboratories with nucleic acid amplification methods, and the robustness of assays the laboratories seek, and what emerging SARS-CoV-2 sensors have currently addressed in the literature. Together with the established nucleic acid and biochemical tests, we review emerging technology and antibody tests to determine the effectiveness of vaccines on individuals.

Original language	English
Pages (from-to)	2815-2837
Number of pages	23
Journal	ACS Sensors
Volume	6
Issue number	8
DOIs	https://doi.org/10.1021/acssensors.1c00612
Publication status	Published - 27 Aug 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

biosensors
clinical tests
coronavirus
electrical sensors
lateral flow devices
mechanical sensors
mutations
optical sensors
PCR
RNA
SARS-CoV-2
sensors

Access to Document

10.1021/acssensors.1c00612

Cite this

@article{a187c5b11c744fd4aa13f6e5a5836d2a,

title = "SARS-CoV-2 Tests: Bridging the Gap between Laboratory Sensors and Clinical Applications",

abstract = "This review covers emerging biosensors for SARS-CoV-2 detection together with a review of the biochemical and clinical assays that are in use in hospitals and clinical laboratories. We discuss the gap in bridging the current practice of testing laboratories with nucleic acid amplification methods, and the robustness of assays the laboratories seek, and what emerging SARS-CoV-2 sensors have currently addressed in the literature. Together with the established nucleic acid and biochemical tests, we review emerging technology and antibody tests to determine the effectiveness of vaccines on individuals.",

keywords = "biosensors, clinical tests, coronavirus, electrical sensors, lateral flow devices, mechanical sensors, mutations, optical sensors, PCR, RNA, SARS-CoV-2, sensors",

author = "Nikita Toropov and Eleanor Osborne and Joshi, \{Lovleen Tina\} and James Davidson and Caitlin Morgan and Joseph Page and Justin Pepperell and Frank Vollmer",

note = "Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",

year = "2021",

month = aug,

day = "27",

doi = "10.1021/acssensors.1c00612",

language = "English",

volume = "6",

pages = "2815--2837",

journal = "ACS Sensors",

issn = "2379-3694",

number = "8",

}

TY - JOUR

T1 - SARS-CoV-2 Tests

T2 - Bridging the Gap between Laboratory Sensors and Clinical Applications

AU - Toropov, Nikita

AU - Osborne, Eleanor

AU - Joshi, Lovleen Tina

AU - Davidson, James

AU - Morgan, Caitlin

AU - Page, Joseph

AU - Pepperell, Justin

AU - Vollmer, Frank

PY - 2021/8/27

Y1 - 2021/8/27

N2 - This review covers emerging biosensors for SARS-CoV-2 detection together with a review of the biochemical and clinical assays that are in use in hospitals and clinical laboratories. We discuss the gap in bridging the current practice of testing laboratories with nucleic acid amplification methods, and the robustness of assays the laboratories seek, and what emerging SARS-CoV-2 sensors have currently addressed in the literature. Together with the established nucleic acid and biochemical tests, we review emerging technology and antibody tests to determine the effectiveness of vaccines on individuals.

AB - This review covers emerging biosensors for SARS-CoV-2 detection together with a review of the biochemical and clinical assays that are in use in hospitals and clinical laboratories. We discuss the gap in bridging the current practice of testing laboratories with nucleic acid amplification methods, and the robustness of assays the laboratories seek, and what emerging SARS-CoV-2 sensors have currently addressed in the literature. Together with the established nucleic acid and biochemical tests, we review emerging technology and antibody tests to determine the effectiveness of vaccines on individuals.

KW - biosensors

KW - clinical tests

KW - coronavirus

KW - electrical sensors

KW - lateral flow devices

KW - mechanical sensors

KW - mutations

KW - optical sensors

KW - PCR

KW - RNA

KW - SARS-CoV-2

KW - sensors

UR - https://www.scopus.com/pages/publications/85114018064

U2 - 10.1021/acssensors.1c00612

DO - 10.1021/acssensors.1c00612

M3 - Review article

C2 - 34392681

AN - SCOPUS:85114018064

SN - 2379-3694

VL - 6

SP - 2815

EP - 2837

JO - ACS Sensors

JF - ACS Sensors

IS - 8

ER -

SARS-CoV-2 Tests: Bridging the Gap between Laboratory Sensors and Clinical Applications

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this