TY - JOUR
T1 - Selective separation of physically near-identical microparticle mixtures by interfacial partitioning
AU - Jauregi, P.
AU - Hoeben, M. A.
AU - Van der Lans, R. G.J.M.
AU - Kwant, G.
AU - Van der Wielen, L. A.M.
PY - 2001/11/28
Y1 - 2001/11/28
N2 - Interfacial partitioning is a novel technology for the separation of physically near-identical particles, which are particles with similar densities and similar sizes but different chemical compositions. Different crystals partition differently to the interface of a biphasic system, forming a substantial interfacial layer (the interphase) as well as a sediment. Here, the selective separation of ampicillin and phenylglycine crystal mixtures in liquid biphasic systems is studied as a model system. In a characteristic batchwise experiment in one step under specific but nonoptimized conditions in water/alkanol biphasic systems, most phenylglycine crystals (80-90% of the feed) adsorb at the interface, whereas the majority of ampicillin crystals (80-90% of the feed) sediment. Important process parameters such as the interfacial loading, the feed crystal composition, and the volume ratio of the liquid phases have been identified, and their influence on the partitioning has been studied. We also discuss a possible mechanism of the interfacial partitioning of the crystals on the basis of the formation of an emulsion in the interphase. This technology has tremendous potential for its application in the selective separation of small bioparticle mixtures.
AB - Interfacial partitioning is a novel technology for the separation of physically near-identical particles, which are particles with similar densities and similar sizes but different chemical compositions. Different crystals partition differently to the interface of a biphasic system, forming a substantial interfacial layer (the interphase) as well as a sediment. Here, the selective separation of ampicillin and phenylglycine crystal mixtures in liquid biphasic systems is studied as a model system. In a characteristic batchwise experiment in one step under specific but nonoptimized conditions in water/alkanol biphasic systems, most phenylglycine crystals (80-90% of the feed) adsorb at the interface, whereas the majority of ampicillin crystals (80-90% of the feed) sediment. Important process parameters such as the interfacial loading, the feed crystal composition, and the volume ratio of the liquid phases have been identified, and their influence on the partitioning has been studied. We also discuss a possible mechanism of the interfacial partitioning of the crystals on the basis of the formation of an emulsion in the interphase. This technology has tremendous potential for its application in the selective separation of small bioparticle mixtures.
UR - http://www.scopus.com/inward/record.url?scp=0035965623&partnerID=8YFLogxK
U2 - 10.1021/ie001024h
DO - 10.1021/ie001024h
M3 - Article
AN - SCOPUS:0035965623
SN - 0888-5885
VL - 40
SP - 5815
EP - 5821
JO - Industrial and Engineering Chemistry Research
JF - Industrial and Engineering Chemistry Research
IS - 24
ER -