Separation and Purification in the Continuous Synthesis of Fine Chemicals and Pharmaceuticals

M. O'Mahony, S. Ferguson, T. Stelzer, A. Myerson

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Of use to both chemists and chemical engineers working in flow synthesis, this chapter provides a summary of separation and purification operations that can be applied to flow synthesis reaction streams. Both single and biphasic separations for the liquid phase are detailed. Separation and purification by continuous crystallization of a solid phase is covered. Continuous solid-liquid separation and drying technologies for the isolation of a fine-chemical or pharmaceutical product are also reviewed.

Original languageEnglish
Title of host publicationScience of Synthesis
EditorsT.F. Jamison, G. Koch
PublisherGeorg Thieme Verlag
Pages51-102
Number of pages52
Edition5
DOIs
Publication statusPublished - 2018

Publication series

NameScience of Synthesis
Number5
Volume2018
ISSN (Print)2510-5469
ISSN (Electronic)2566-7297

Keywords

  • continuous crystallization
  • continuous filtration
  • continuous isolation and drying
  • continuous separation
  • continuous solid liquid separation
  • filtration
  • flow chemistry
  • integrated continuous manufacturing
  • membrane extractors
  • nanofiltration
  • pharmaceuticals

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