Separation of Trimethoxybenzene Isomers by Bile Acids

Jacky S. Bouanga Boudiombo; Hong Su; Susan A. Bourne; Luigi R. Nassimbeni

doi:10.1021/acs.cgd.7b01423

Separation of Trimethoxybenzene Isomers by Bile Acids

Jacky S. Bouanga Boudiombo
, Hong Su
, Susan A. Bourne
, Luigi R. Nassimbeni

University of Cape Town

Research output: Contribution to journal › Article › peer-review

Abstract

Cholic acid (CA) and deoxycholic acid (DCA) have been employed to separate the three isomers of trimethoxybenzene (TMB). The selectivity preference is CA: TMB135 > TMB123 ≈ TMB124, while it is reversed for DCA: TMB123 > TMB124 > TMB135. Some of the crystal structures with CA as host suffered from partial disorder, while the DCA structures were grown from pairs of equimolar guest mixtures, and all contained both guests in different proportions. Packing analysis revealed the importance of layering of the hydrophilic and lipophilic regions of the structures with the TMB guests accommodated in the lipophilic layers.

Original language	English
Pages (from-to)	424-430
Number of pages	7
Journal	Crystal Growth and Design
Volume	18
Issue number	1
DOIs	https://doi.org/10.1021/acs.cgd.7b01423
Publication status	Published - 3 Jan 2018
Externally published	Yes

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title = "Separation of Trimethoxybenzene Isomers by Bile Acids",

abstract = "Cholic acid (CA) and deoxycholic acid (DCA) have been employed to separate the three isomers of trimethoxybenzene (TMB). The selectivity preference is CA: TMB135 > TMB123 ≈ TMB124, while it is reversed for DCA: TMB123 > TMB124 > TMB135. Some of the crystal structures with CA as host suffered from partial disorder, while the DCA structures were grown from pairs of equimolar guest mixtures, and all contained both guests in different proportions. Packing analysis revealed the importance of layering of the hydrophilic and lipophilic regions of the structures with the TMB guests accommodated in the lipophilic layers.",

author = "\{Bouanga Boudiombo\}, \{Jacky S.\} and Hong Su and Bourne, \{Susan A.\} and Nassimbeni, \{Luigi R.\}",

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doi = "10.1021/acs.cgd.7b01423",

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AU - Bouanga Boudiombo, Jacky S.

AU - Su, Hong

AU - Bourne, Susan A.

AU - Nassimbeni, Luigi R.

PY - 2018/1/3

Y1 - 2018/1/3

N2 - Cholic acid (CA) and deoxycholic acid (DCA) have been employed to separate the three isomers of trimethoxybenzene (TMB). The selectivity preference is CA: TMB135 > TMB123 ≈ TMB124, while it is reversed for DCA: TMB123 > TMB124 > TMB135. Some of the crystal structures with CA as host suffered from partial disorder, while the DCA structures were grown from pairs of equimolar guest mixtures, and all contained both guests in different proportions. Packing analysis revealed the importance of layering of the hydrophilic and lipophilic regions of the structures with the TMB guests accommodated in the lipophilic layers.

AB - Cholic acid (CA) and deoxycholic acid (DCA) have been employed to separate the three isomers of trimethoxybenzene (TMB). The selectivity preference is CA: TMB135 > TMB123 ≈ TMB124, while it is reversed for DCA: TMB123 > TMB124 > TMB135. Some of the crystal structures with CA as host suffered from partial disorder, while the DCA structures were grown from pairs of equimolar guest mixtures, and all contained both guests in different proportions. Packing analysis revealed the importance of layering of the hydrophilic and lipophilic regions of the structures with the TMB guests accommodated in the lipophilic layers.

UR - https://www.scopus.com/pages/publications/85040162661

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DO - 10.1021/acs.cgd.7b01423

M3 - Article

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SN - 1528-7483

VL - 18

SP - 424

EP - 430

JO - Crystal Growth and Design

JF - Crystal Growth and Design

IS - 1

ER -

Separation of Trimethoxybenzene Isomers by Bile Acids

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