Severe Aortic Valvular Incompetence From IgG4-Related Disease: An Unusual Entity

Bing Wei Thaddeus Soh; Sophie Catherine Prendergast; Louise Burke; Cormac T. O'Connor; Ihsan Ullah; Julie M. O'Brien; John A. Hinchion; Samer Arnous; Thomas J. Kiernan

doi:10.1016/j.jaccas.2023.102027

Severe Aortic Valvular Incompetence From IgG4-Related Disease: An Unusual Entity

Bing Wei Thaddeus Soh, Sophie Catherine Prendergast, Louise Burke, Cormac T. O'Connor, Ihsan Ullah, Julie M. O'Brien, John A. Hinchion, Samer Arnous, Thomas J. Kiernan

Research output: Contribution to journal › Article › peer-review

Abstract

IgG4-related disease (IgG4-RD) is a new clinical entity characterized by lymphoplasmacytic lesions rich in IgG4-positive plasma cells. Myocardial involvement is extremely rare and not a typical cardiovascular manifestation of IgG4-RD. We report a rare case of IgG4-RD–associated myocardial mass causing severe aortic incompetence, successfully treated with surgery and corticosteroids. (Level of Difficulty: Intermediate.)

Original language	English
Article number	102027
Pages (from-to)	102027
Journal	JACC: Case Reports
Volume	24
DOIs	https://doi.org/10.1016/j.jaccas.2023.102027
Publication status	Published - 18 Oct 2023
Externally published	Yes

Keywords

cardiac mass
IgG4-RD
IgG4-related disease
multimodal imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jaccas.2023.102027

Cite this

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title = "Severe Aortic Valvular Incompetence From IgG4-Related Disease: An Unusual Entity",

abstract = "IgG4-related disease (IgG4-RD) is a new clinical entity characterized by lymphoplasmacytic lesions rich in IgG4-positive plasma cells. Myocardial involvement is extremely rare and not a typical cardiovascular manifestation of IgG4-RD. We report a rare case of IgG4-RD–associated myocardial mass causing severe aortic incompetence, successfully treated with surgery and corticosteroids. (Level of Difficulty: Intermediate.)",

keywords = "cardiac mass, IgG4-RD, IgG4-related disease, multimodal imaging",

author = "Soh, {Bing Wei Thaddeus} and Prendergast, {Sophie Catherine} and Louise Burke and O'Connor, {Cormac T.} and Ihsan Ullah and O'Brien, {Julie M.} and Hinchion, {John A.} and Samer Arnous and Kiernan, {Thomas J.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = oct,

day = "18",

doi = "10.1016/j.jaccas.2023.102027",

language = "English",

volume = "24",

pages = "102027",

journal = "JACC: Case Reports",

issn = "2666-0849",

}

TY - JOUR

T1 - Severe Aortic Valvular Incompetence From IgG4-Related Disease

T2 - An Unusual Entity

AU - Soh, Bing Wei Thaddeus

AU - Prendergast, Sophie Catherine

AU - Burke, Louise

AU - O'Connor, Cormac T.

AU - Ullah, Ihsan

AU - O'Brien, Julie M.

AU - Hinchion, John A.

AU - Arnous, Samer

AU - Kiernan, Thomas J.

PY - 2023/10/18

Y1 - 2023/10/18

N2 - IgG4-related disease (IgG4-RD) is a new clinical entity characterized by lymphoplasmacytic lesions rich in IgG4-positive plasma cells. Myocardial involvement is extremely rare and not a typical cardiovascular manifestation of IgG4-RD. We report a rare case of IgG4-RD–associated myocardial mass causing severe aortic incompetence, successfully treated with surgery and corticosteroids. (Level of Difficulty: Intermediate.)

AB - IgG4-related disease (IgG4-RD) is a new clinical entity characterized by lymphoplasmacytic lesions rich in IgG4-positive plasma cells. Myocardial involvement is extremely rare and not a typical cardiovascular manifestation of IgG4-RD. We report a rare case of IgG4-RD–associated myocardial mass causing severe aortic incompetence, successfully treated with surgery and corticosteroids. (Level of Difficulty: Intermediate.)

KW - cardiac mass

KW - IgG4-RD

KW - IgG4-related disease

KW - multimodal imaging

UR - http://www.scopus.com/inward/record.url?scp=85171173680&partnerID=8YFLogxK

U2 - 10.1016/j.jaccas.2023.102027

DO - 10.1016/j.jaccas.2023.102027

M3 - Article

AN - SCOPUS:85171173680

SN - 2666-0849

VL - 24

SP - 102027

JO - JACC: Case Reports

JF - JACC: Case Reports

M1 - 102027

ER -

Severe Aortic Valvular Incompetence From IgG4-Related Disease: An Unusual Entity

Abstract

Keywords

UN SDGs

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