Severe Aortic Valvular Incompetence From IgG4-Related Disease: An Unusual Entity

Bing Wei Thaddeus Soh; Sophie Catherine Prendergast; Louise Burke; Cormac T. O'Connor; Ihsan Ullah; Julie M. O'Brien; John A. Hinchion; Samer Arnous; Thomas J. Kiernan

doi:10.1016/j.jaccas.2023.102027

Severe Aortic Valvular Incompetence From IgG4-Related Disease: An Unusual Entity

Bing Wei Thaddeus Soh, Sophie Catherine Prendergast, Louise Burke, Cormac T. O'Connor, Ihsan Ullah, Julie M. O'Brien, John A. Hinchion, Samer Arnous, Thomas J. Kiernan

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

IgG4-related disease (IgG4-RD) is a new clinical entity characterized by lymphoplasmacytic lesions rich in IgG4-positive plasma cells. Myocardial involvement is extremely rare and not a typical cardiovascular manifestation of IgG4-RD. We report a rare case of IgG4-RD–associated myocardial mass causing severe aortic incompetence, successfully treated with surgery and corticosteroids. (Level of Difficulty: Intermediate.)

Original language	English
Article number	102027
Journal	JACC: Case Reports
Volume	24
DOIs	https://doi.org/10.1016/j.jaccas.2023.102027
Publication status	Published - 18 Oct 2023

Keywords

IgG4-RD
IgG4-related disease
cardiac mass
multimodal imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jaccas.2023.102027

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title = "Severe Aortic Valvular Incompetence From IgG4-Related Disease: An Unusual Entity",

abstract = "IgG4-related disease (IgG4-RD) is a new clinical entity characterized by lymphoplasmacytic lesions rich in IgG4-positive plasma cells. Myocardial involvement is extremely rare and not a typical cardiovascular manifestation of IgG4-RD. We report a rare case of IgG4-RD–associated myocardial mass causing severe aortic incompetence, successfully treated with surgery and corticosteroids. (Level of Difficulty: Intermediate.)",

keywords = "IgG4-RD, IgG4-related disease, cardiac mass, multimodal imaging",

author = "Soh, \{Bing Wei Thaddeus\} and Prendergast, \{Sophie Catherine\} and Louise Burke and O'Connor, \{Cormac T.\} and Ihsan Ullah and O'Brien, \{Julie M.\} and Hinchion, \{John A.\} and Samer Arnous and Kiernan, \{Thomas J.\}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = oct,

day = "18",

doi = "10.1016/j.jaccas.2023.102027",

language = "English",

volume = "24",

journal = "JACC: Case Reports",

issn = "2666-0849",

}

TY - JOUR

T1 - Severe Aortic Valvular Incompetence From IgG4-Related Disease

T2 - An Unusual Entity

AU - Soh, Bing Wei Thaddeus

AU - Prendergast, Sophie Catherine

AU - Burke, Louise

AU - O'Connor, Cormac T.

AU - Ullah, Ihsan

AU - O'Brien, Julie M.

AU - Hinchion, John A.

AU - Arnous, Samer

AU - Kiernan, Thomas J.

PY - 2023/10/18

Y1 - 2023/10/18

N2 - IgG4-related disease (IgG4-RD) is a new clinical entity characterized by lymphoplasmacytic lesions rich in IgG4-positive plasma cells. Myocardial involvement is extremely rare and not a typical cardiovascular manifestation of IgG4-RD. We report a rare case of IgG4-RD–associated myocardial mass causing severe aortic incompetence, successfully treated with surgery and corticosteroids. (Level of Difficulty: Intermediate.)

AB - IgG4-related disease (IgG4-RD) is a new clinical entity characterized by lymphoplasmacytic lesions rich in IgG4-positive plasma cells. Myocardial involvement is extremely rare and not a typical cardiovascular manifestation of IgG4-RD. We report a rare case of IgG4-RD–associated myocardial mass causing severe aortic incompetence, successfully treated with surgery and corticosteroids. (Level of Difficulty: Intermediate.)

KW - IgG4-RD

KW - IgG4-related disease

KW - cardiac mass

KW - multimodal imaging

UR - https://www.scopus.com/pages/publications/85171173680

U2 - 10.1016/j.jaccas.2023.102027

DO - 10.1016/j.jaccas.2023.102027

M3 - Article

AN - SCOPUS:85171173680

SN - 2666-0849

VL - 24

JO - JACC: Case Reports

JF - JACC: Case Reports

M1 - 102027

ER -

Severe Aortic Valvular Incompetence From IgG4-Related Disease: An Unusual Entity

Abstract

Keywords

UN SDGs

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