Solid and Solution State Thermodynamics of Polymorphs of Butamben (Butyl 4-Aminobenzoate) in Pure Organic Solvents

Michael Svärd, Lai Zeng, Masood Valavi, Gamid Rama Krishna, Åke C. Rasmuson

Research output: Contribution to journalArticlepeer-review

Abstract

The solubility of butamben has been measured gravimetrically in pure methanol, 1-propanol, 2-propanol, 1-butanol, and toluene over the temperature range 268-298 K. Polymorph transition and melting temperatures, associated enthalpy changes, and the heat capacity of the solid forms and the supercooled melt have been measured by differential scanning calorimetry. Based on extrapolated calorimetric data, the Gibbs energy, enthalpy and entropy of fusion, and the activity of solid butamben (the ideal solubility) have been calculated from below ambient temperature up to the melting point. Activity coefficients of butamben at equilibrium in the different solvents have been estimated from solubility data and the activity of the solid, revealing that all investigated systems exhibit positive deviation from Raoult's law. Solubility data are well correlated by a semiempirical regression model. On a mass basis, the solubility is clearly higher in methanol than in the other solvents, but mole fraction solubilities are very similar across all 5 solvents. The 2 known polymorphs are enantiotropically related, and the transition point is located at 283 K. Polymorph interconversions occur within 0.3 K of the transition point even in the solid state, and the 2 forms exhibit strong similarities in investigated properties.

Original languageEnglish
Pages (from-to)2377-2382
Number of pages6
JournalJournal of Pharmaceutical Sciences
Volume108
Issue number7
DOIs
Publication statusPublished - Jul 2019

Keywords

  • activity coefficient
  • crystallization
  • differential scanning calorimetry (DSC)
  • polymorphism
  • solubility
  • thermal analysis
  • X-ray powder diffraction (XRD)

Fingerprint

Dive into the research topics of 'Solid and Solution State Thermodynamics of Polymorphs of Butamben (Butyl 4-Aminobenzoate) in Pure Organic Solvents'. Together they form a unique fingerprint.

Cite this