Abstract
The search for solid solutions of class-two insulin secretagogues, tolbutamide and chlorpropamide, reveals a rare case of monotropic polymorphism for the mixed crystals. At any stoichiometry, two crystal forms are isolated that are kinetically stable at room temperature from a few months to over a year. Dissolution tests certify the solubility advantage of the solid solutions over the pure drugs as well as their physical mixture, suggesting a potential application as a highly soluble co-drug formulation.
Original language | English |
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Pages (from-to) | 14321-14324 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 59 |
Issue number | 96 |
DOIs | |
Publication status | Published - 10 Nov 2023 |