Solid solution polymorphs afford two highly soluble co-drug forms of tolbutamide and chlorpropamide

Enrico Spoletti, Vivek Verma, Chiara Cappuccino, Matteo Lusi

Research output: Contribution to journalArticlepeer-review

Abstract

The search for solid solutions of class-two insulin secretagogues, tolbutamide and chlorpropamide, reveals a rare case of monotropic polymorphism for the mixed crystals. At any stoichiometry, two crystal forms are isolated that are kinetically stable at room temperature from a few months to over a year. Dissolution tests certify the solubility advantage of the solid solutions over the pure drugs as well as their physical mixture, suggesting a potential application as a highly soluble co-drug formulation.

Original languageEnglish
Pages (from-to)14321-14324
Number of pages4
JournalChemical Communications
Volume59
Issue number96
DOIs
Publication statusPublished - 10 Nov 2023

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