TY - JOUR
T1 - Solubility of fumaric acid and its monosodium salt
AU - Roa Engel, Carol A.
AU - Ter Horst, Joop H.
AU - Pieterse, Mervin
AU - Van Der Wielen, Luuk A.M.
AU - Straathof, Adrie J.J.
PY - 2013/7/10
Y1 - 2013/7/10
N2 - Fumaric acid is a dicarboxylic acid applied in food industry and in some polymers. Currently, its fermentative production from renewable resources is receiving much attention, and crystallization is used to recover it. To determine the window of operation for crystallization from multicomponent fermentation mixtures, the aqueous solubilities of fumaric acid and its sodium salts were investigated. For fumaric acid, sodium hydrogen fumarate, and sodium fumarate, solubilities and pH increased in this order because of increasing polarity and dissociation. A mathematical model was developed to predict crystal type and amount as function of temperature and pH. The effect of glucose (up to 3.0 mmol·mol-1) on the solubility can be neglected, but ethanol (1.0 mmol·mol-1) slightly increased the solubility of fumaric acid and significantly decreased the solubility of the sodium salts, because the aqueous solution becomes less polar upon ethanol addition but not upon glucose addition.
AB - Fumaric acid is a dicarboxylic acid applied in food industry and in some polymers. Currently, its fermentative production from renewable resources is receiving much attention, and crystallization is used to recover it. To determine the window of operation for crystallization from multicomponent fermentation mixtures, the aqueous solubilities of fumaric acid and its sodium salts were investigated. For fumaric acid, sodium hydrogen fumarate, and sodium fumarate, solubilities and pH increased in this order because of increasing polarity and dissociation. A mathematical model was developed to predict crystal type and amount as function of temperature and pH. The effect of glucose (up to 3.0 mmol·mol-1) on the solubility can be neglected, but ethanol (1.0 mmol·mol-1) slightly increased the solubility of fumaric acid and significantly decreased the solubility of the sodium salts, because the aqueous solution becomes less polar upon ethanol addition but not upon glucose addition.
UR - http://www.scopus.com/inward/record.url?scp=84880000058&partnerID=8YFLogxK
U2 - 10.1021/ie400794r
DO - 10.1021/ie400794r
M3 - Article
AN - SCOPUS:84880000058
SN - 0888-5885
VL - 52
SP - 9454
EP - 9460
JO - Industrial and Engineering Chemistry Research
JF - Industrial and Engineering Chemistry Research
IS - 27
ER -