Solubility of paracetamol in pure solvents

Roger A. Granberg, Åke C. Rasmuson

Research output: Contribution to journalArticlepeer-review

Abstract

The solubility of paracetamol (4-hydroxyacetanilide) in 26 solvents in the temperature range from -5 to +30°C is reported. Paracetamol has a very low solubility in nonpolar and chlorinated hydrocarbons such as toluene and carbon tetrachloride whereas the solubility is very high in solvents of medium polarity such as N,N-dimethylformamide, dimethyl sulfoxide, and diethylamine. Paracetamol is soluble in alcohols, but the solubility decreases with an increase in the length of the carbon chain in the n-alcohol homologous series (methanol to 1-octanol). The solubility of paracetamol in water is much lower than in other polar solvents such as the alcohols. The ideal solubility of paracetamol is calculated, and the activity coefficient in the saturated solutions is estimated.

Original languageEnglish
Pages (from-to)1391-1395
Number of pages5
JournalJournal of Chemical and Engineering Data
Volume44
Issue number6
DOIs
Publication statusPublished - Nov 1999
Externally publishedYes

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