TY - JOUR
T1 - Solubility of Salicylic Acid, Salicylamide, and Fenofibrate in Organic Solvents at Low Temperatures
AU - Sadeghi, Masoud
AU - Rasmuson, Åke C.
N1 - Publisher Copyright:
© 2020 American Chemical Society.
PY - 2020/10/8
Y1 - 2020/10/8
N2 - In the present work, the solubility of salicylic acid, salicylamide, and fenofibrate (form I) has been determined in acetone, acetonitrile, ethyl acetate, and methanol in the range of -30 to +10 °C. Salicylic acid and salicylamide have the highest solubility in acetone and the lowest in acetonitrile. Fenofibrate has the highest solubility in ethyl acetate and the lowest in methanol. In all solvents except for acetonitrile, the solubility of salicylic acid is higher than the solubility of the other two compounds. In all solvents except for ethyl acetate, the solubility of fenofibrate is lower than the solubility of the other two compounds. In all cases, the solubility increases with increasing temperature and agrees well with the previously published data at higher temperatures. Finally, an empirical equation is fitted to the experimental data.
AB - In the present work, the solubility of salicylic acid, salicylamide, and fenofibrate (form I) has been determined in acetone, acetonitrile, ethyl acetate, and methanol in the range of -30 to +10 °C. Salicylic acid and salicylamide have the highest solubility in acetone and the lowest in acetonitrile. Fenofibrate has the highest solubility in ethyl acetate and the lowest in methanol. In all solvents except for acetonitrile, the solubility of salicylic acid is higher than the solubility of the other two compounds. In all solvents except for ethyl acetate, the solubility of fenofibrate is lower than the solubility of the other two compounds. In all cases, the solubility increases with increasing temperature and agrees well with the previously published data at higher temperatures. Finally, an empirical equation is fitted to the experimental data.
UR - http://www.scopus.com/inward/record.url?scp=85092118955&partnerID=8YFLogxK
U2 - 10.1021/acs.jced.0c00443
DO - 10.1021/acs.jced.0c00443
M3 - Article
AN - SCOPUS:85092118955
SN - 0021-9568
VL - 65
SP - 4855
EP - 4861
JO - Journal of Chemical and Engineering Data
JF - Journal of Chemical and Engineering Data
IS - 10
ER -