Solution crystallization kinetics of 6-aminopenicillanic acid

Juliana S. Ferreira; Adrie J.J. Straathof; Xiaonan Li; Marcel Ottens; Telma T. Franco; Luuk A.M. Van Der Wielen

doi:10.1021/ie0601652

Solution crystallization kinetics of 6-aminopenicillanic acid

Juliana S. Ferreira, Adrie J.J. Straathof, Xiaonan Li, Marcel Ottens, Telma T. Franco, Luuk A.M. Van Der Wielen

Research output: Contribution to journal › Article › peer-review

Abstract

Semisynthetic penicillins, derived from 6-aminopenicillanic acid (APA), constitute an important group of antibiotics. APA is produced by enzymatic hydrolysis of penicillin G (PenG). This study concerns the determination of the crystallization kinetics of APA in the presence of other components that may be present after the PenG hydrolysis, i.e., remaining PenG and the byproduct phenylacetic acid. This evaluation is based on the analyses of growth rate and crystal size distribution, at pH 4 and 5. The results show that the impurities have no significant influence on the APA crystallization, within the range of pH and impurity concentrations evaluated. A mathematical model, based on the population balance, gives a good prediction of the crystallization rate and crystal size distribution with a single set of parameters.

Original language	English
Pages (from-to)	6740-6744
Number of pages	5
Journal	Industrial and Engineering Chemistry Research
Volume	45
Issue number	20
DOIs	https://doi.org/10.1021/ie0601652
Publication status	Published - 27 Sep 2006
Externally published	Yes

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title = "Solution crystallization kinetics of 6-aminopenicillanic acid",

abstract = "Semisynthetic penicillins, derived from 6-aminopenicillanic acid (APA), constitute an important group of antibiotics. APA is produced by enzymatic hydrolysis of penicillin G (PenG). This study concerns the determination of the crystallization kinetics of APA in the presence of other components that may be present after the PenG hydrolysis, i.e., remaining PenG and the byproduct phenylacetic acid. This evaluation is based on the analyses of growth rate and crystal size distribution, at pH 4 and 5. The results show that the impurities have no significant influence on the APA crystallization, within the range of pH and impurity concentrations evaluated. A mathematical model, based on the population balance, gives a good prediction of the crystallization rate and crystal size distribution with a single set of parameters.",

author = "Ferreira, {Juliana S.} and Straathof, {Adrie J.J.} and Xiaonan Li and Marcel Ottens and Franco, {Telma T.} and {Van Der Wielen}, {Luuk A.M.}",

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T1 - Solution crystallization kinetics of 6-aminopenicillanic acid

AU - Ferreira, Juliana S.

AU - Straathof, Adrie J.J.

AU - Li, Xiaonan

AU - Ottens, Marcel

AU - Franco, Telma T.

AU - Van Der Wielen, Luuk A.M.

PY - 2006/9/27

Y1 - 2006/9/27

N2 - Semisynthetic penicillins, derived from 6-aminopenicillanic acid (APA), constitute an important group of antibiotics. APA is produced by enzymatic hydrolysis of penicillin G (PenG). This study concerns the determination of the crystallization kinetics of APA in the presence of other components that may be present after the PenG hydrolysis, i.e., remaining PenG and the byproduct phenylacetic acid. This evaluation is based on the analyses of growth rate and crystal size distribution, at pH 4 and 5. The results show that the impurities have no significant influence on the APA crystallization, within the range of pH and impurity concentrations evaluated. A mathematical model, based on the population balance, gives a good prediction of the crystallization rate and crystal size distribution with a single set of parameters.

AB - Semisynthetic penicillins, derived from 6-aminopenicillanic acid (APA), constitute an important group of antibiotics. APA is produced by enzymatic hydrolysis of penicillin G (PenG). This study concerns the determination of the crystallization kinetics of APA in the presence of other components that may be present after the PenG hydrolysis, i.e., remaining PenG and the byproduct phenylacetic acid. This evaluation is based on the analyses of growth rate and crystal size distribution, at pH 4 and 5. The results show that the impurities have no significant influence on the APA crystallization, within the range of pH and impurity concentrations evaluated. A mathematical model, based on the population balance, gives a good prediction of the crystallization rate and crystal size distribution with a single set of parameters.

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DO - 10.1021/ie0601652

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AN - SCOPUS:33749870919

SN - 0888-5885

VL - 45

SP - 6740

EP - 6744

JO - Industrial and Engineering Chemistry Research

JF - Industrial and Engineering Chemistry Research

IS - 20

ER -

Solution crystallization kinetics of 6-aminopenicillanic acid

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