Solution mediated phase transformations between co-crystals

Denise M. Croker, Roger J. Davey, Åke C. Rasmuson, Colin C. Seaton

Research output: Contribution to journalArticlepeer-review

Abstract

A solution mediated transformation between two co-crystal phases has been observed for the p-toluensulfonamide-triphenylphosphine oxide co-crystal system. This system has two known co-crystals with 1 : 1 and 3 : 2 stoichiometry respectively, and the ternary phase diagram (TPD) for the system has been determined in acetonitrile previously. By manipulating the solution composition in this solvent to a region of the TPD where the 1 : 1 co-crystal is stable, the 3 : 2 co-crystal could be observed to convert to the 1 : 1 co-crystal. The corresponding transformation was true for the 1 : 1 co-crystal in a region of the TPD where the 3 : 2 co-crystal is stable; the 1 : 1 co-crystal converted to the 3 : 2 co-crystal.

Original languageEnglish
Pages (from-to)2044-2047
Number of pages4
JournalCrystEngComm
Volume15
Issue number11
DOIs
Publication statusPublished - 21 Mar 2013

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