Solution-mediated polymorphic transformation: Form II to Form III piracetam in organic solvents

Anthony Maher; Denise M. Croker; Colin C. Seaton; Åke C. Rasmuson; Benjamin K. Hodnett

doi:10.1021/cg500565u

Solution-mediated polymorphic transformation: Form II to Form III piracetam in organic solvents

Anthony Maher, Denise M. Croker, Colin C. Seaton, Åke C. Rasmuson, Benjamin K. Hodnett

Retired Staff

University of Limerick

Research output: Contribution to journal › Article › peer-review

Abstract

The solution-mediated polymorphic transformation from Form II to Form III 2-oxo-1-pyrrolidine acetamide (piracetam) was investigated in seven organic solvents over the temperature range of 5-50 °C. The transformation rate increased as a function of temperature, agitation, and the solubility of piracetam in the host solvent. However, this trend was reversed in 2-propanol. Molecular modeling demonstrated that 2-propanol forms interactions with piracetam molecules in solution stronger than those formed by other solvents, thereby retarding the nucleation and growth of FIII(6.525) during the transformation in this solvent.

Original language	English
Pages (from-to)	3967-3974
Number of pages	8
Journal	Crystal Growth and Design
Volume	14
Issue number	8
DOIs	https://doi.org/10.1021/cg500565u
Publication status	Published - 6 Aug 2014

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title = "Solution-mediated polymorphic transformation: Form II to Form III piracetam in organic solvents",

abstract = "The solution-mediated polymorphic transformation from Form II to Form III 2-oxo-1-pyrrolidine acetamide (piracetam) was investigated in seven organic solvents over the temperature range of 5-50 °C. The transformation rate increased as a function of temperature, agitation, and the solubility of piracetam in the host solvent. However, this trend was reversed in 2-propanol. Molecular modeling demonstrated that 2-propanol forms interactions with piracetam molecules in solution stronger than those formed by other solvents, thereby retarding the nucleation and growth of FIII(6.525) during the transformation in this solvent.",

author = "Anthony Maher and Croker, {Denise M.} and Seaton, {Colin C.} and Rasmuson, {{\AA}ke C.} and Hodnett, {Benjamin K.}",

year = "2014",

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AU - Rasmuson, Åke C.

AU - Hodnett, Benjamin K.

PY - 2014/8/6

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AB - The solution-mediated polymorphic transformation from Form II to Form III 2-oxo-1-pyrrolidine acetamide (piracetam) was investigated in seven organic solvents over the temperature range of 5-50 °C. The transformation rate increased as a function of temperature, agitation, and the solubility of piracetam in the host solvent. However, this trend was reversed in 2-propanol. Molecular modeling demonstrated that 2-propanol forms interactions with piracetam molecules in solution stronger than those formed by other solvents, thereby retarding the nucleation and growth of FIII(6.525) during the transformation in this solvent.

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JO - Crystal Growth and Design

JF - Crystal Growth and Design

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ER -

Solution-mediated polymorphic transformation: Form II to Form III piracetam in organic solvents

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