Solution-mediated polymorphic transformation: Form II to Form III piracetam in organic solvents

Anthony Maher; Denise M. Croker; Colin C. Seaton; Åke C. Rasmuson; Benjamin K. Hodnett

doi:10.1021/cg500565u

Solution-mediated polymorphic transformation: Form II to Form III piracetam in organic solvents

Anthony Maher
, Denise M. Croker
, Colin C. Seaton
, Åke C. Rasmuson
, Benjamin K. Hodnett

Retired Staff

University of Limerick

Research output: Contribution to journal › Article › peer-review

Abstract

The solution-mediated polymorphic transformation from Form II to Form III 2-oxo-1-pyrrolidine acetamide (piracetam) was investigated in seven organic solvents over the temperature range of 5-50 °C. The transformation rate increased as a function of temperature, agitation, and the solubility of piracetam in the host solvent. However, this trend was reversed in 2-propanol. Molecular modeling demonstrated that 2-propanol forms interactions with piracetam molecules in solution stronger than those formed by other solvents, thereby retarding the nucleation and growth of FIII(6.525) during the transformation in this solvent.

Original language	English
Pages (from-to)	3967-3974
Number of pages	8
Journal	Crystal Growth and Design
Volume	14
Issue number	8
DOIs	https://doi.org/10.1021/cg500565u
Publication status	Published - 6 Aug 2014

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title = "Solution-mediated polymorphic transformation: Form II to Form III piracetam in organic solvents",

abstract = "The solution-mediated polymorphic transformation from Form II to Form III 2-oxo-1-pyrrolidine acetamide (piracetam) was investigated in seven organic solvents over the temperature range of 5-50 °C. The transformation rate increased as a function of temperature, agitation, and the solubility of piracetam in the host solvent. However, this trend was reversed in 2-propanol. Molecular modeling demonstrated that 2-propanol forms interactions with piracetam molecules in solution stronger than those formed by other solvents, thereby retarding the nucleation and growth of FIII(6.525) during the transformation in this solvent.",

author = "Anthony Maher and Croker, \{Denise M.\} and Seaton, \{Colin C.\} and Rasmuson, \{{\AA}ke C.\} and Hodnett, \{Benjamin K.\}",

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doi = "10.1021/cg500565u",

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journal = "Crystal Growth and Design",

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AU - Maher, Anthony

AU - Croker, Denise M.

AU - Seaton, Colin C.

AU - Rasmuson, Åke C.

AU - Hodnett, Benjamin K.

PY - 2014/8/6

Y1 - 2014/8/6

N2 - The solution-mediated polymorphic transformation from Form II to Form III 2-oxo-1-pyrrolidine acetamide (piracetam) was investigated in seven organic solvents over the temperature range of 5-50 °C. The transformation rate increased as a function of temperature, agitation, and the solubility of piracetam in the host solvent. However, this trend was reversed in 2-propanol. Molecular modeling demonstrated that 2-propanol forms interactions with piracetam molecules in solution stronger than those formed by other solvents, thereby retarding the nucleation and growth of FIII(6.525) during the transformation in this solvent.

AB - The solution-mediated polymorphic transformation from Form II to Form III 2-oxo-1-pyrrolidine acetamide (piracetam) was investigated in seven organic solvents over the temperature range of 5-50 °C. The transformation rate increased as a function of temperature, agitation, and the solubility of piracetam in the host solvent. However, this trend was reversed in 2-propanol. Molecular modeling demonstrated that 2-propanol forms interactions with piracetam molecules in solution stronger than those formed by other solvents, thereby retarding the nucleation and growth of FIII(6.525) during the transformation in this solvent.

UR - https://www.scopus.com/pages/publications/84905716828

U2 - 10.1021/cg500565u

DO - 10.1021/cg500565u

M3 - Article

AN - SCOPUS:84905716828

SN - 1528-7483

VL - 14

SP - 3967

EP - 3974

JO - Crystal Growth and Design

JF - Crystal Growth and Design

IS - 8

ER -

Solution-mediated polymorphic transformation: Form II to Form III piracetam in organic solvents

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