Solution-mediated polymorphic transformation of FV sulphathiazole

Áine Munroe; Denise M. Croker; Åke C. Rasmuson; Benjamin K. Hodnett

doi:10.1021/cg500395e

Solution-mediated polymorphic transformation of FV sulphathiazole

Áine Munroe, Denise M. Croker, Åke C. Rasmuson, Benjamin K. Hodnett

Retired Staff

University of Limerick

Research output: Contribution to journal › Article › peer-review

Abstract

The solution-mediated polymorphic transformation of FV sulphathiazole was investigated in ethanol at 10°C. Powder X-ray diffraction (PXRD) identified the transformation product as a mixture of FII and FIV sulphathiazole. This mixture remained stable in solution at 10°C with agitation for 24 h. In situ temperature controlled optical microscopy enabled visualization of the transformation in real time, allowing elucidation of the transformation mechanism. A modest amount of dissolution of FV sulphathiazole preceded the nucleation of FII and FIV crystals, which were detected simultaneously. Thereafter, these polymorphs grew rapidly. Experimental evidence is presented for a mechanism, whereby nucleation of FII and FIV was initiated on the roughened surface of the dissolving FV crystals, without any indication for a spatially extended structural relationship between the host form V and the nucleating phases. Subsequent growth of FII and FIV crystals consumed the remaining FV crystals completing the dissolution-recrystallization mechanism.

Original language	English
Pages (from-to)	3466-3471
Number of pages	6
Journal	Crystal Growth and Design
Volume	14
Issue number	7
DOIs	https://doi.org/10.1021/cg500395e
Publication status	Published - 2 Jul 2014

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title = "Solution-mediated polymorphic transformation of FV sulphathiazole",

abstract = "The solution-mediated polymorphic transformation of FV sulphathiazole was investigated in ethanol at 10°C. Powder X-ray diffraction (PXRD) identified the transformation product as a mixture of FII and FIV sulphathiazole. This mixture remained stable in solution at 10°C with agitation for 24 h. In situ temperature controlled optical microscopy enabled visualization of the transformation in real time, allowing elucidation of the transformation mechanism. A modest amount of dissolution of FV sulphathiazole preceded the nucleation of FII and FIV crystals, which were detected simultaneously. Thereafter, these polymorphs grew rapidly. Experimental evidence is presented for a mechanism, whereby nucleation of FII and FIV was initiated on the roughened surface of the dissolving FV crystals, without any indication for a spatially extended structural relationship between the host form V and the nucleating phases. Subsequent growth of FII and FIV crystals consumed the remaining FV crystals completing the dissolution-recrystallization mechanism.",

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T1 - Solution-mediated polymorphic transformation of FV sulphathiazole

AU - Munroe, Áine

AU - Croker, Denise M.

AU - Rasmuson, Åke C.

AU - Hodnett, Benjamin K.

PY - 2014/7/2

Y1 - 2014/7/2

N2 - The solution-mediated polymorphic transformation of FV sulphathiazole was investigated in ethanol at 10°C. Powder X-ray diffraction (PXRD) identified the transformation product as a mixture of FII and FIV sulphathiazole. This mixture remained stable in solution at 10°C with agitation for 24 h. In situ temperature controlled optical microscopy enabled visualization of the transformation in real time, allowing elucidation of the transformation mechanism. A modest amount of dissolution of FV sulphathiazole preceded the nucleation of FII and FIV crystals, which were detected simultaneously. Thereafter, these polymorphs grew rapidly. Experimental evidence is presented for a mechanism, whereby nucleation of FII and FIV was initiated on the roughened surface of the dissolving FV crystals, without any indication for a spatially extended structural relationship between the host form V and the nucleating phases. Subsequent growth of FII and FIV crystals consumed the remaining FV crystals completing the dissolution-recrystallization mechanism.

AB - The solution-mediated polymorphic transformation of FV sulphathiazole was investigated in ethanol at 10°C. Powder X-ray diffraction (PXRD) identified the transformation product as a mixture of FII and FIV sulphathiazole. This mixture remained stable in solution at 10°C with agitation for 24 h. In situ temperature controlled optical microscopy enabled visualization of the transformation in real time, allowing elucidation of the transformation mechanism. A modest amount of dissolution of FV sulphathiazole preceded the nucleation of FII and FIV crystals, which were detected simultaneously. Thereafter, these polymorphs grew rapidly. Experimental evidence is presented for a mechanism, whereby nucleation of FII and FIV was initiated on the roughened surface of the dissolving FV crystals, without any indication for a spatially extended structural relationship between the host form V and the nucleating phases. Subsequent growth of FII and FIV crystals consumed the remaining FV crystals completing the dissolution-recrystallization mechanism.

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Solution-mediated polymorphic transformation of FV sulphathiazole

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