TY - JOUR
T1 - Sources of declarative memory impairment in bipolar disorder
T2 - Mnemonic processes and clinical features
AU - Bearden, Carrie E.
AU - Glahn, David C.
AU - Monkul, E. Serap
AU - Barrett, Jennifer
AU - Najt, Pablo
AU - Kaur, Simerjit
AU - Sanches, Marsal
AU - Villarreal, Veronica
AU - Bowden, Charles
AU - Soares, Jair C.
PY - 2006/2
Y1 - 2006/2
N2 - Background: There is mounting evidence that declarative memory processes are impaired in patients with bipolar disorder. However, predictors of the observed impairment are not well understood. This study seeks to: (i) better characterize the nature of declarative memory impairment in bipolar disorder, and (ii) determine the relationship between clinical variables and memory function in bipolar disorder. Methods: 49 adult patients with bipolar disorder in varying mood states and 38 demographically matched healthy participants completed a comprehensive neurocognitive battery assessing general cognitive functioning, processing speed, and declarative memory. The California verbal learning test was used to characterize learning and memory functions. Results: Although patients with bipolar disorder utilized a similar semantic clustering strategy to healthy controls, they recalled and recognized significantly fewer words than controls, suggesting impaired encoding of verbal information. In contrast, lack of rapid forgetting suggests relative absence of a storage deficit in bipolar patients. While severity of mood symptomatology and illness duration were not associated with task performance, gender and family history significantly affected memory function. Conclusions: Results suggest that declarative memory impairments in bipolar patients: (1) are consistent with deficits in learning, but do not appear to be related to different organizational strategies during learning, and (2) do not appear to be secondary to clinical state, but rather may be associated with the underlying pathophysiology of the illness.
AB - Background: There is mounting evidence that declarative memory processes are impaired in patients with bipolar disorder. However, predictors of the observed impairment are not well understood. This study seeks to: (i) better characterize the nature of declarative memory impairment in bipolar disorder, and (ii) determine the relationship between clinical variables and memory function in bipolar disorder. Methods: 49 adult patients with bipolar disorder in varying mood states and 38 demographically matched healthy participants completed a comprehensive neurocognitive battery assessing general cognitive functioning, processing speed, and declarative memory. The California verbal learning test was used to characterize learning and memory functions. Results: Although patients with bipolar disorder utilized a similar semantic clustering strategy to healthy controls, they recalled and recognized significantly fewer words than controls, suggesting impaired encoding of verbal information. In contrast, lack of rapid forgetting suggests relative absence of a storage deficit in bipolar patients. While severity of mood symptomatology and illness duration were not associated with task performance, gender and family history significantly affected memory function. Conclusions: Results suggest that declarative memory impairments in bipolar patients: (1) are consistent with deficits in learning, but do not appear to be related to different organizational strategies during learning, and (2) do not appear to be secondary to clinical state, but rather may be associated with the underlying pathophysiology of the illness.
KW - Bipolar disorder
KW - Clinical state
KW - Cognition
KW - Declarative memory
KW - Gender
UR - http://www.scopus.com/inward/record.url?scp=30944434816&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2005.08.006
DO - 10.1016/j.jpsychires.2005.08.006
M3 - Article
C2 - 16199055
AN - SCOPUS:30944434816
SN - 0022-3956
VL - 40
SP - 47
EP - 58
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 1
ER -