Squaratides: a tunable platform for anion binding in peptide-inspired macrocycles

Farhad Ali Mohammed; Hua Tong; Chris S. Hawes; Shayon Bhattacharya; Damien Thompson; Katrina A. Jolliffe; Robert B.P. Elmes

doi:10.1039/d6cc00836d

Squaratides: a tunable platform for anion binding in peptide-inspired macrocycles

Farhad Ali Mohammed
, Hua Tong
, Chris S. Hawes
, Shayon Bhattacharya
, Damien Thompson
, Katrina A. Jolliffe
, Robert B.P. Elmes

Maynooth University
University of Limerick
Keele University
University of Sydney

Research output: Contribution to journal › Article › peer-review

Abstract

We report a new class of sequence-defined peptidomimetic macrocycles, termed squaratides, that incorporate squaramide units into a tunable peptide backbone. These modular receptors can bind acetate and chloride ions where sidechain functionality can control affinity and stoichiometry.

Original language	English
Pages (from-to)	8417-8421
Number of pages	5
Journal	Chemical Communications
Volume	62
Issue number	33
DOIs	https://doi.org/10.1039/d6cc00836d
Publication status	Published - 30 Apr 2026

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title = "Squaratides: a tunable platform for anion binding in peptide-inspired macrocycles",

abstract = "We report a new class of sequence-defined peptidomimetic macrocycles, termed squaratides, that incorporate squaramide units into a tunable peptide backbone. These modular receptors can bind acetate and chloride ions where sidechain functionality can control affinity and stoichiometry.",

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AU - Hawes, Chris S.

AU - Bhattacharya, Shayon

AU - Thompson, Damien

AU - Jolliffe, Katrina A.

AU - Elmes, Robert B.P.

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AB - We report a new class of sequence-defined peptidomimetic macrocycles, termed squaratides, that incorporate squaramide units into a tunable peptide backbone. These modular receptors can bind acetate and chloride ions where sidechain functionality can control affinity and stoichiometry.

UR - https://www.scopus.com/pages/publications/105035642610

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JO - Chemical Communications

JF - Chemical Communications

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Squaratides: a tunable platform for anion binding in peptide-inspired macrocycles

Abstract

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