Static and dynamic degradation of sintered calcium phosphate ceramics

C. Newe, E. Cunningham, F. Buchanan, G. Walker, P. Prendergast, A. Lennon, N. Dunne

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The chemical compositions of calcium phosphate materials are similar to that of bone making them very attractive for use in the repair of critical size bone defects. The bioresorption of calcium phosphate occurs principally by dissolution. To determine the impact of composition and flow conditions on dissolution rates, calcium phosphate tablets were prepared by slip casting of ceramic slips with different ratios of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). Dissolution was evaluated at pH4 using both a static and dynamic flow regime. Both the composition of the HA:β-TCP tablet and flow regime noticeably influenced the rate of dissolution; the 50:50 HA:β- TCP composition demonstrating the greatest level of dissolution, and, exposure of the ceramic specimens to dynamic conditions producing the highest rate of dissolution. Understanding the impact of phase composition and flow condition with respect to the dissolution of calcium phosphate will aid in the development and improvement of materials for bone substitution.

Original languageEnglish
Title of host publicationBioceramics 23
PublisherTrans Tech Publications Ltd
Pages861-865
Number of pages5
ISBN (Print)9783037852552
DOIs
Publication statusPublished - 2012
Externally publishedYes
Event23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011 - Istanbul, Turkey
Duration: 6 Nov 20119 Nov 2011

Publication series

NameKey Engineering Materials
Volume493-494
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Conference

Conference23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011
Country/TerritoryTurkey
CityIstanbul
Period6/11/119/11/11

Keywords

  • Calcium phosphate
  • Dissolution
  • Scaffold

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