Structural study of salicylic acid salts of a series of azacycles and azacrown ethers

Marina S. Fonari, Eduard V. Ganin, Stepan S. Basok, Konstantin A. Lyssenko, Michael J. Zaworotko, Victor Ch Kravtsov

Research output: Contribution to journalArticlepeer-review

Abstract

Interaction of salicylic acid (saH) with the azacycles piperidine (pipe) and meso-5,7,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane (teta) and with the aza-crown ethers aza-12-crown-4 (A12C4), benzoaza-15-crown-5 (BA15C5), aza-18-crown-6 (A18C6), and diaza-18-crown-6 (DA18C6) afforded the proton-transfer complexes (organic salts) of compositions [pipeH][sa], [tetaH2][sa]2, [A12C4H][sa], [BA15C5H][sa], [A18C6H][sa]•2H2O, and [DA18C6H2][sa] 2•3H2O, whose structures were determined by a single crystal X-ray method. These products were also obtained by the same synthetic conditions starting from acetylsalicylic acid (aspirin) as a result of hydrolysis. The charge-assisted N-H•••O hydrogen-bond provides the main driving force for direct binding of sa with cyclic azonia cations. The crystal packing is also supported by weak C-H•••O hydrogen bonding and edge-to-face π•••π intermolecular interactions.

Original languageEnglish
Pages (from-to)5210-5220
Number of pages11
JournalCrystal Growth and Design
Volume10
Issue number12
DOIs
Publication statusPublished - 1 Dec 2010
Externally publishedYes

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