Study of three solvates of sulfamethazine

Dipali Ahuja; Pauric Bannigan; Åke C. Rasmuson

doi:10.1039/c7ce01610g

Study of three solvates of sulfamethazine

Dipali Ahuja, Pauric Bannigan, Åke C. Rasmuson

Retired Staff

University of Limerick

Research output: Contribution to journal › Article › peer-review

Abstract

Three novel solvates of sulfamethazine (SMT), an anti-microbial and anti-infective sulfonamide drug with the solvents-dimethylacetamide, dimethylformamide and dimethyl sulfoxide have been identified and characterized by analytical techniques including differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction and Raman spectroscopy. All three are 1:1 solvates. Crystal structure analysis revealed N-H-O type intermolecular hydrogen bonding interactions between SMT and the solvent imparting stability to the solvate structure. Thermal analysis measurements for the stoichiometry of the solvates were in good agreement with the single crystal data. The solubility of the solvates in their respective solvents at 25 °C has been determined.

Original language	English
Pages (from-to)	6481-6488
Number of pages	8
Journal	CrystEngComm
Volume	19
Issue number	43
DOIs	https://doi.org/10.1039/c7ce01610g
Publication status	Published - 2017

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abstract = "Three novel solvates of sulfamethazine (SMT), an anti-microbial and anti-infective sulfonamide drug with the solvents-dimethylacetamide, dimethylformamide and dimethyl sulfoxide have been identified and characterized by analytical techniques including differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction and Raman spectroscopy. All three are 1:1 solvates. Crystal structure analysis revealed N-H-O type intermolecular hydrogen bonding interactions between SMT and the solvent imparting stability to the solvate structure. Thermal analysis measurements for the stoichiometry of the solvates were in good agreement with the single crystal data. The solubility of the solvates in their respective solvents at 25 °C has been determined.",

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AU - Bannigan, Pauric

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AB - Three novel solvates of sulfamethazine (SMT), an anti-microbial and anti-infective sulfonamide drug with the solvents-dimethylacetamide, dimethylformamide and dimethyl sulfoxide have been identified and characterized by analytical techniques including differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction and Raman spectroscopy. All three are 1:1 solvates. Crystal structure analysis revealed N-H-O type intermolecular hydrogen bonding interactions between SMT and the solvent imparting stability to the solvate structure. Thermal analysis measurements for the stoichiometry of the solvates were in good agreement with the single crystal data. The solubility of the solvates in their respective solvents at 25 °C has been determined.

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Study of three solvates of sulfamethazine

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