TY - JOUR
T1 - Superparamagnetic Gadolinium Ferrite Nanoparticles with Controllable Curie Temperature – Cancer Theranostics for MR-Imaging-Guided Magneto-Chemotherapy
AU - Thorat, Nanasaheb D.
AU - Bohara, Raghvendra A.
AU - Tofail, Syed A.M.
AU - Alothman, Zeid Abdullah
AU - Shiddiky, Muhammad J.A.
AU - A Hossain, Md Shahriar
AU - Yamauchi, Yusuke
AU - Wu, Kevin C.W.
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2016/10
Y1 - 2016/10
N2 - A facile polyol approach for preparing low-Curie-temperature (TC) gadolinium-doped iron oxide nanoparticles (GdIO NPs) for targeted magnetic hyperthermia and chemotherapy coupled with T1–T2dual-model magnetic resonance (MR) imaging (where T1and T2are the longitudinal and transverse relaxation times, respectively) is reported. A small amount of Gd doping decreases the TCof iron oxide down to about 400 K. In the presence of ethanolamine, controlled polyol synthesis leads to the formation of low-TC, highly magnetic (52.87 emu g–1), and size-controlled (ca. 10 nm) GdIO NPs. A further conjugation with folate and a chemotherapeutic drug has been developed, and the whole system is used for in vitro magneto-chemotherapy (magnetic hyperthermia and chemotherapy) for cancer treatment. The synthesized GdIO NPs are stable colloids that are hemocompatible and cytocompatible over a wide concentration range and have a high affinity towards cancer cells. The release of a chemotherapeutic drug from the GdIO NPs significantly affects cancer cell viability, and the T1–T2dual-model magnetic resonance enhances bioimaging in a breast cancer cell model. We suggest that the chemotherapeutic-drug-conjugated GdIO NPs have great potential for cell targeting and magnetic resonance imaging in cancer magneto-chemotherapy.
AB - A facile polyol approach for preparing low-Curie-temperature (TC) gadolinium-doped iron oxide nanoparticles (GdIO NPs) for targeted magnetic hyperthermia and chemotherapy coupled with T1–T2dual-model magnetic resonance (MR) imaging (where T1and T2are the longitudinal and transverse relaxation times, respectively) is reported. A small amount of Gd doping decreases the TCof iron oxide down to about 400 K. In the presence of ethanolamine, controlled polyol synthesis leads to the formation of low-TC, highly magnetic (52.87 emu g–1), and size-controlled (ca. 10 nm) GdIO NPs. A further conjugation with folate and a chemotherapeutic drug has been developed, and the whole system is used for in vitro magneto-chemotherapy (magnetic hyperthermia and chemotherapy) for cancer treatment. The synthesized GdIO NPs are stable colloids that are hemocompatible and cytocompatible over a wide concentration range and have a high affinity towards cancer cells. The release of a chemotherapeutic drug from the GdIO NPs significantly affects cancer cell viability, and the T1–T2dual-model magnetic resonance enhances bioimaging in a breast cancer cell model. We suggest that the chemotherapeutic-drug-conjugated GdIO NPs have great potential for cell targeting and magnetic resonance imaging in cancer magneto-chemotherapy.
KW - Gadolinium
KW - Imaging agents
KW - Magnetic properties
KW - Nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=84984706719&partnerID=8YFLogxK
U2 - 10.1002/ejic.201600706
DO - 10.1002/ejic.201600706
M3 - Article
AN - SCOPUS:84984706719
SN - 1434-1948
VL - 2016
SP - 4586
EP - 4597
JO - European Journal of Inorganic Chemistry
JF - European Journal of Inorganic Chemistry
IS - 28
ER -