Superparamagnetic Gadolinium Ferrite Nanoparticles with Controllable Curie Temperature – Cancer Theranostics for MR-Imaging-Guided Magneto-Chemotherapy

Nanasaheb D. Thorat, Raghvendra A. Bohara, Syed A.M. Tofail, Zeid Abdullah Alothman, Muhammad J.A. Shiddiky, Md Shahriar A Hossain, Yusuke Yamauchi, Kevin C.W. Wu

Research output: Contribution to journalArticlepeer-review

Abstract

A facile polyol approach for preparing low-Curie-temperature (TC) gadolinium-doped iron oxide nanoparticles (GdIO NPs) for targeted magnetic hyperthermia and chemotherapy coupled with T1–T2dual-model magnetic resonance (MR) imaging (where T1and T2are the longitudinal and transverse relaxation times, respectively) is reported. A small amount of Gd doping decreases the TCof iron oxide down to about 400 K. In the presence of ethanolamine, controlled polyol synthesis leads to the formation of low-TC, highly magnetic (52.87 emu g–1), and size-controlled (ca. 10 nm) GdIO NPs. A further conjugation with folate and a chemotherapeutic drug has been developed, and the whole system is used for in vitro magneto-chemotherapy (magnetic hyperthermia and chemotherapy) for cancer treatment. The synthesized GdIO NPs are stable colloids that are hemocompatible and cytocompatible over a wide concentration range and have a high affinity towards cancer cells. The release of a chemotherapeutic drug from the GdIO NPs significantly affects cancer cell viability, and the T1–T2dual-model magnetic resonance enhances bioimaging in a breast cancer cell model. We suggest that the chemotherapeutic-drug-conjugated GdIO NPs have great potential for cell targeting and magnetic resonance imaging in cancer magneto-chemotherapy.

Original languageEnglish
Pages (from-to)4586-4597
Number of pages12
JournalEuropean Journal of Inorganic Chemistry
Volume2016
Issue number28
DOIs
Publication statusPublished - Oct 2016

Keywords

  • Gadolinium
  • Imaging agents
  • Magnetic properties
  • Nanoparticles

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