Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients

Rajendran Harishkumar, Sakshi Hans, Janelle E. Stanton, Andreas M. Grabrucker, Ronan Lordan, Ioannis Zabetakis

Research output: Contribution to journalReview articlepeer-review

Abstract

Platelet-activating factor (PAF) is a lipid mediator that interacts with its receptor (PAF-R) to carry out cell signalling. However, under certain conditions the binding of PAF to PAF-R leads to the activation of pro-inflammatory and prothrombotic pathways that have been implicated in the onset and development of atherosclerotic cardiovascular diseases (CVD) and inflammatory diseases. Over the past four decades, research has focused on the identification and development of PAF-R antagonists that target these inflammatory diseases. Research has also shown that dietary factors such as polar lipids, polyphenols, and other nutrient constituents may affect PAF metabolism and PAF-R function through various mechanisms. In this review we focus on the inhibition of PAF-R and how this may contribute to reducing cardiovascular disease risk. We conclude that further development of PAF-R inhibitors and human studies are required to investigate how modulation of the PAF-R may prevent the development of atherosclerotic cardiovascular disease and may lead to the development of novel therapeutics.

Original languageEnglish
Article number4414
JournalNutrients
Volume14
Issue number20
DOIs
Publication statusPublished - Oct 2022

Keywords

  • antithrombotic activity
  • atherosclerosis
  • inflammation
  • platelet-activating factor
  • platelet-activating factor receptor
  • polar lipids

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