TY - JOUR
T1 - Targeting the Platelet-Activating Factor Receptor (PAF-R)
T2 - Antithrombotic and Anti-Atherosclerotic Nutrients
AU - Harishkumar, Rajendran
AU - Hans, Sakshi
AU - Stanton, Janelle E.
AU - Grabrucker, Andreas M.
AU - Lordan, Ronan
AU - Zabetakis, Ioannis
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/10
Y1 - 2022/10
N2 - Platelet-activating factor (PAF) is a lipid mediator that interacts with its receptor (PAF-R) to carry out cell signalling. However, under certain conditions the binding of PAF to PAF-R leads to the activation of pro-inflammatory and prothrombotic pathways that have been implicated in the onset and development of atherosclerotic cardiovascular diseases (CVD) and inflammatory diseases. Over the past four decades, research has focused on the identification and development of PAF-R antagonists that target these inflammatory diseases. Research has also shown that dietary factors such as polar lipids, polyphenols, and other nutrient constituents may affect PAF metabolism and PAF-R function through various mechanisms. In this review we focus on the inhibition of PAF-R and how this may contribute to reducing cardiovascular disease risk. We conclude that further development of PAF-R inhibitors and human studies are required to investigate how modulation of the PAF-R may prevent the development of atherosclerotic cardiovascular disease and may lead to the development of novel therapeutics.
AB - Platelet-activating factor (PAF) is a lipid mediator that interacts with its receptor (PAF-R) to carry out cell signalling. However, under certain conditions the binding of PAF to PAF-R leads to the activation of pro-inflammatory and prothrombotic pathways that have been implicated in the onset and development of atherosclerotic cardiovascular diseases (CVD) and inflammatory diseases. Over the past four decades, research has focused on the identification and development of PAF-R antagonists that target these inflammatory diseases. Research has also shown that dietary factors such as polar lipids, polyphenols, and other nutrient constituents may affect PAF metabolism and PAF-R function through various mechanisms. In this review we focus on the inhibition of PAF-R and how this may contribute to reducing cardiovascular disease risk. We conclude that further development of PAF-R inhibitors and human studies are required to investigate how modulation of the PAF-R may prevent the development of atherosclerotic cardiovascular disease and may lead to the development of novel therapeutics.
KW - antithrombotic activity
KW - atherosclerosis
KW - inflammation
KW - platelet-activating factor
KW - platelet-activating factor receptor
KW - polar lipids
UR - http://www.scopus.com/inward/record.url?scp=85140792268&partnerID=8YFLogxK
U2 - 10.3390/nu14204414
DO - 10.3390/nu14204414
M3 - Review article
C2 - 36297097
AN - SCOPUS:85140792268
SN - 2072-6643
VL - 14
JO - Nutrients
JF - Nutrients
IS - 20
M1 - 4414
ER -