Targeting the tumor microenvironment: Potential strategy for cancer therapeutics

Quratulain Babar, Ayesha Saeed, Tanveer A. Tabish, Mohsin Sarwar, Nanasaheb D. Thorat

Research output: Contribution to journalReview articlepeer-review

Abstract

Cellular and stromal components including tumor cells, immune cells, mesenchymal cells, cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment (TME). TME plays a crucial role in reprogramming tumor initiation, uncontrolled proliferation, invasion and metastasis as well as response to therapeutic modalities. In recent years targeting the TME has developed as a potential strategy for treatment of cancer because of its life-threatening functions in restricting tumor development and modulating responses to standard-of-care medicines. Cold atmospheric plasma, oncolytic viral therapy, bacterial therapy, nano-vaccine, and repurposed pharmaceuticals with combination therapy, antiangiogenic drugs, and immunotherapies are among the most effective therapies directed by TME that have either been clinically authorized or are currently being studied. This article discusses above-mentioned therapies in light of targeting TME. We also cover problems related to the TME-targeted therapies, as well as future insights and practical uses in this rapidly growing field.

Original languageEnglish
Article number166746
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1869
Issue number6
DOIs
Publication statusPublished - Aug 2023

Keywords

  • Immunotherapy
  • Oncolytic virus
  • Repurposed drugs
  • Tumor associated macrophage
  • Tumor microenvironment

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