TY - JOUR
T1 - Techno-economic evaluation of solvent impregnated particles in a bioreactor
AU - Van Den Berg, Corjan
AU - Boon, Floor
AU - Roelands, Mark
AU - Bussmann, Paul
AU - Goetheer, Earl
AU - Verdoes, Dirk
AU - Van Der Wielen, Luuk
PY - 2010/9/6
Y1 - 2010/9/6
N2 - Most fermentation products have a feedback inhibiting effect on the host organism. In situ product recovery (ISPR) can be a means to overcome this product inhibition in fermentations. Particles such as solvent impregnated resins or capsules can be valuable tools for product recovery based on extraction. To evaluate, which kind of particle will be feasible for a certain kind of fermentation product an evaluation is presented here. Furthermore, an assessment is made what the impact is of ISPR for enhancing productivities in relatively non-inhibiting (lactic acid), fairly inhibiting (phenol) and severely inhibiting (erythromycin) fermentation products. A process containing solvent impregnated resins or capsules is evaluated based on enhanced productivities and cost-effectiveness. It is shown that applying these particles inside a fermentor can result in a decrease in ±30% of total manufacturing costs for pharma-intermediate production.
AB - Most fermentation products have a feedback inhibiting effect on the host organism. In situ product recovery (ISPR) can be a means to overcome this product inhibition in fermentations. Particles such as solvent impregnated resins or capsules can be valuable tools for product recovery based on extraction. To evaluate, which kind of particle will be feasible for a certain kind of fermentation product an evaluation is presented here. Furthermore, an assessment is made what the impact is of ISPR for enhancing productivities in relatively non-inhibiting (lactic acid), fairly inhibiting (phenol) and severely inhibiting (erythromycin) fermentation products. A process containing solvent impregnated resins or capsules is evaluated based on enhanced productivities and cost-effectiveness. It is shown that applying these particles inside a fermentor can result in a decrease in ±30% of total manufacturing costs for pharma-intermediate production.
KW - Capsules
KW - Erythromycin
KW - Extraction
KW - In-sit product removal
KW - Lactic acid
KW - Phenol
KW - Solvent impregnated resins
UR - http://www.scopus.com/inward/record.url?scp=78049449801&partnerID=8YFLogxK
U2 - 10.1016/j.seppur.2010.06.022
DO - 10.1016/j.seppur.2010.06.022
M3 - Article
AN - SCOPUS:78049449801
SN - 1383-5866
VL - 74
SP - 318
EP - 328
JO - Separation and Purification Technology
JF - Separation and Purification Technology
IS - 3
ER -