TY - JOUR
T1 - The bioactivity and ion release of titanium-containing glass polyalkenoate cements for medical applications
AU - Wren, A. W.
AU - Cummins, N. M.
AU - Laffir, F. R.
AU - Hudson, S. P.
AU - Towler, M. R.
PY - 2011/1
Y1 - 2011/1
N2 - The ion release profiles and bioactivity of a series of Ti containing glass polyalkenoate cements. Characterization revealed each material to be amorphous with a T g in the region of 650-660°C. The network connectivity decreased (1.83-1.35) with the addition of TiO2 which was also evident with analysis by X-ray photoelectron spectroscopy. Ion release from cements were determined using atomic absorption spectroscopy for zinc (Zn 2+), calcium (Ca2+), strontium (Sr2+), Silica (Si4+) and titanium (Ti4+). Ions such as Zn2+ (0.1-2.0 mg/l), Ca2+ (2.0-8.3 mg/l,) Sr2+ (0.1-3.9 mg/l), and Si4+ (14-90 mg/l) were tested over 1-30 days. No Ti4+ release was detected. Simulated body fluid revealed a CaP surface layer on each cement while cell culture testing of cement liquid extracts with TW-Z (5 mol% TiO2) produced the highest cell viability (161%) after 30 days. Direct contact testing of discs resulted in a decrease in cell viability of the each cement tested.
AB - The ion release profiles and bioactivity of a series of Ti containing glass polyalkenoate cements. Characterization revealed each material to be amorphous with a T g in the region of 650-660°C. The network connectivity decreased (1.83-1.35) with the addition of TiO2 which was also evident with analysis by X-ray photoelectron spectroscopy. Ion release from cements were determined using atomic absorption spectroscopy for zinc (Zn 2+), calcium (Ca2+), strontium (Sr2+), Silica (Si4+) and titanium (Ti4+). Ions such as Zn2+ (0.1-2.0 mg/l), Ca2+ (2.0-8.3 mg/l,) Sr2+ (0.1-3.9 mg/l), and Si4+ (14-90 mg/l) were tested over 1-30 days. No Ti4+ release was detected. Simulated body fluid revealed a CaP surface layer on each cement while cell culture testing of cement liquid extracts with TW-Z (5 mol% TiO2) produced the highest cell viability (161%) after 30 days. Direct contact testing of discs resulted in a decrease in cell viability of the each cement tested.
UR - http://www.scopus.com/inward/record.url?scp=78751601115&partnerID=8YFLogxK
U2 - 10.1007/s10856-010-4184-4
DO - 10.1007/s10856-010-4184-4
M3 - Article
C2 - 21076857
AN - SCOPUS:78751601115
SN - 0957-4530
VL - 22
SP - 19
EP - 28
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
IS - 1
ER -