Abstract
Like the systemic inflammatory response syndrome (SIRS), the compensatory anti-inflammatory response syndrome (CARS) is a complex pattern of immunologic responses to severe infection or injury. The difference is that while SIRS is a proinflammatory response tasked with killing infectious organisms through activation of the immune system, CARS is a global deactivation of the immune system tasked with restoring homeostasis. Much research now suggests that the timing and relative magnitude of this response have a profound impact on patient outcomes.
Original language | English |
---|---|
Pages (from-to) | 617-625 |
Number of pages | 9 |
Journal | Clinics in Chest Medicine |
Volume | 29 |
Issue number | 4 |
DOIs | |
Publication status | Published - Dec 2008 |
Externally published | Yes |
Keywords
- Anergy
- Anti-inflammatory
- Compensatory anti-inflammatory response syndrome
- Human leukocyte antigen
- Sepsis
- Systemic inflammatory response syndrome