The Compensatory Anti-inflammatory Response Syndrome (CARS) in Critically Ill Patients

Nicholas S. Ward, Brian Casserly, Alfred Ayala

Research output: Contribution to journalReview articlepeer-review

Abstract

Like the systemic inflammatory response syndrome (SIRS), the compensatory anti-inflammatory response syndrome (CARS) is a complex pattern of immunologic responses to severe infection or injury. The difference is that while SIRS is a proinflammatory response tasked with killing infectious organisms through activation of the immune system, CARS is a global deactivation of the immune system tasked with restoring homeostasis. Much research now suggests that the timing and relative magnitude of this response have a profound impact on patient outcomes.

Original languageEnglish
Pages (from-to)617-625
Number of pages9
JournalClinics in Chest Medicine
Volume29
Issue number4
DOIs
Publication statusPublished - Dec 2008
Externally publishedYes

Keywords

  • Anergy
  • Anti-inflammatory
  • Compensatory anti-inflammatory response syndrome
  • Human leukocyte antigen
  • Sepsis
  • Systemic inflammatory response syndrome

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