The development of a pharmaceutical oral solid dosage forms

Rahamatullah Shaikh; Dónal P. O'Brien; Denise M. Croker; Gavin M. Walker

doi:10.1016/B978-0-444-63963-9.00002-6

The development of a pharmaceutical oral solid dosage forms

Rahamatullah Shaikh
, Dónal P. O'Brien
, Denise M. Croker
, Gavin M. Walker

University of Limerick

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Among the various drug delivery routes, the oral route has long been the most popular and convenient route. In this chapter, we focus on the development of oral solid dosage forms including preformulation, drug product development, and manufacturing. Preformulation addresses the impact of physicochemical characteristics of the API and excipients on the goal of designing the optimum formulation. Formulation development outlines the key aspects of the different methods used for tablet production. Further development of the manufacturing process focuses on the process system engineering applied to unit operation design (process development and manufacturing of tablet formulation) and how particular unit operations can be optimized to drive down the cost and increase process robustness.

Original language	English
Title of host publication	Computer Aided Chemical Engineering
Publisher	Elsevier B.V.
Pages	27-65
Number of pages	39
DOIs	https://doi.org/10.1016/B978-0-444-63963-9.00002-6
Publication status	Published - 2018

Publication series

Name	Computer Aided Chemical Engineering
Volume	41
ISSN (Print)	1570-7946

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Keywords

Formulation development
Manufacturing of tablet formulation
Oral solid dosage form
Preformulation
Process system engineering
Quality by Design (QbD)

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10.1016/B978-0-444-63963-9.00002-6

Cite this

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title = "The development of a pharmaceutical oral solid dosage forms",

abstract = "Among the various drug delivery routes, the oral route has long been the most popular and convenient route. In this chapter, we focus on the development of oral solid dosage forms including preformulation, drug product development, and manufacturing. Preformulation addresses the impact of physicochemical characteristics of the API and excipients on the goal of designing the optimum formulation. Formulation development outlines the key aspects of the different methods used for tablet production. Further development of the manufacturing process focuses on the process system engineering applied to unit operation design (process development and manufacturing of tablet formulation) and how particular unit operations can be optimized to drive down the cost and increase process robustness.",

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language = "English",

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AU - Croker, Denise M.

AU - Walker, Gavin M.

PY - 2018

Y1 - 2018

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AB - Among the various drug delivery routes, the oral route has long been the most popular and convenient route. In this chapter, we focus on the development of oral solid dosage forms including preformulation, drug product development, and manufacturing. Preformulation addresses the impact of physicochemical characteristics of the API and excipients on the goal of designing the optimum formulation. Formulation development outlines the key aspects of the different methods used for tablet production. Further development of the manufacturing process focuses on the process system engineering applied to unit operation design (process development and manufacturing of tablet formulation) and how particular unit operations can be optimized to drive down the cost and increase process robustness.

KW - Formulation development

KW - Manufacturing of tablet formulation

KW - Oral solid dosage form

KW - Preformulation

KW - Process system engineering

KW - Quality by Design (QbD)

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M3 - Chapter

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T3 - Computer Aided Chemical Engineering

SP - 27

EP - 65

BT - Computer Aided Chemical Engineering

PB - Elsevier B.V.

ER -

The development of a pharmaceutical oral solid dosage forms

Abstract

Publication series

UN SDGs

Keywords

Access to Document

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