TY - JOUR
T1 - The Dimensionality of Hydrogen Bond Networks Induces Diverse Physical Properties of Peptide Crystals
AU - Yuan, Hui
AU - Cazade, Pierre Andre
AU - Yuan, Chengqian
AU - Xue, Bin
AU - Kumar, Vijay Bhooshan
AU - Yang, Rusen
AU - Finkelstein-Zuta, Gal
AU - Gershon, Lihi
AU - Lahav, Maoz
AU - Rencus-Lazar, Sigal
AU - Cao, Yi
AU - Levy, Davide
AU - Thompson, Damien
AU - Gazit, Ehud
N1 - Publisher Copyright:
© 2024 The Authors. Published by American Chemical Society.
PY - 2024/8/5
Y1 - 2024/8/5
N2 - Short peptides are attractive building blocks for the fabrication of self-assembled materials with significant biological, chemical, and physical properties. The microscopic and macroscopic properties of assemblies are usually closely related to the dimensionality of formed hydrogen bond networks. Here, two completely different supramolecular architectures connected by distinct hydrogen bond networks were obtained by simply adding a hydroxyl group to switch from cyclo-tryptophan-alanine (cyclo-WA) to cyclo-tryptophan-serine (cyclo-WS). While hydroxyl-bearing cyclo-WS molecules provided an additional hydrogen bond donor that links to adjacent molecules, forming a rigid three-dimensional network, cyclo-WA arranged into a water-mediated zipper-like structure with a softer two-dimensional layer template. This subtle alteration resulted in a 14-fold enhancement of Young’s modulus values in cyclo-WS compared to cyclo-WA. Both cyclo-dipeptides exhibit biocompatibility, high fluorescence, and piezoelectricity. The demonstrated role of dimensionality of hydrogen bond networks opens new avenues for rational design of materials with precise morphologies and customizable properties for bioelectronic applications.
AB - Short peptides are attractive building blocks for the fabrication of self-assembled materials with significant biological, chemical, and physical properties. The microscopic and macroscopic properties of assemblies are usually closely related to the dimensionality of formed hydrogen bond networks. Here, two completely different supramolecular architectures connected by distinct hydrogen bond networks were obtained by simply adding a hydroxyl group to switch from cyclo-tryptophan-alanine (cyclo-WA) to cyclo-tryptophan-serine (cyclo-WS). While hydroxyl-bearing cyclo-WS molecules provided an additional hydrogen bond donor that links to adjacent molecules, forming a rigid three-dimensional network, cyclo-WA arranged into a water-mediated zipper-like structure with a softer two-dimensional layer template. This subtle alteration resulted in a 14-fold enhancement of Young’s modulus values in cyclo-WS compared to cyclo-WA. Both cyclo-dipeptides exhibit biocompatibility, high fluorescence, and piezoelectricity. The demonstrated role of dimensionality of hydrogen bond networks opens new avenues for rational design of materials with precise morphologies and customizable properties for bioelectronic applications.
UR - http://www.scopus.com/inward/record.url?scp=85199425245&partnerID=8YFLogxK
U2 - 10.1021/acsmaterialslett.4c00665
DO - 10.1021/acsmaterialslett.4c00665
M3 - Article
AN - SCOPUS:85199425245
SN - 2639-4979
VL - 6
SP - 3824
EP - 3833
JO - ACS Materials Letters
JF - ACS Materials Letters
IS - 8
ER -