The effect of chronically administered mianserin, 8-hydroxymianserin and desmethylmianserin on the ‘open field’ behaviour and brain noradrenaline metabolism in the olfactory bulbectomized rat

B. E. Leonard; W. T. O’Connor

doi:10.1159/000118404

The effect of chronically administered mianserin, 8-hydroxymianserin and desmethylmianserin on the ‘open field’ behaviour and brain noradrenaline metabolism in the olfactory bulbectomized rat

B. E. Leonard
, W. T. O’Connor

Research output: Contribution to journal › Article › peer-review

Abstract

The chronic effects of mianserin and two of its major metabolites on the behaviour of olfactory bulbectomized rats in the ‘open field’ apparatus were studied. When these compounds were tested at the same dose, only the parent compound was active in attenuating the hypermotility which the bulbectomized rat exhibited under these experimental conditions. Changes in the concentrations of noradrenaline and 3-methoxy-4-hydroxyphenylglycol (MHPG) were also determined in the amygdaloid cortex and mid-brain regions of the sham-operated and lesioned rats. Only mianserin reversed the reduction in the noradrenaline concentration which occurred in the amygdaloid cortex following bulbectomy; the changes in noradrenaline or MHPG in the mid-brain were not correlated with this behavioural effect of mianserin.

Original language	English
Pages (from-to)	118-121
Number of pages	4
Journal	Neuropsychobiology
Volume	18
Issue number	3
DOIs	https://doi.org/10.1159/000118404
Publication status	Published - 1987
Externally published	Yes

Keywords

3-Methoxy-4-hydroxyphenylgIycol
8-Hydroxymianserin
Brain noradrenaline
Desmethylmianserin
Mianserin
Olfactory’ bulbectomy

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title = "The effect of chronically administered mianserin, 8-hydroxymianserin and desmethylmianserin on the {\textquoteleft}open field{\textquoteright} behaviour and brain noradrenaline metabolism in the olfactory bulbectomized rat",

abstract = "The chronic effects of mianserin and two of its major metabolites on the behaviour of olfactory bulbectomized rats in the {\textquoteleft}open field{\textquoteright} apparatus were studied. When these compounds were tested at the same dose, only the parent compound was active in attenuating the hypermotility which the bulbectomized rat exhibited under these experimental conditions. Changes in the concentrations of noradrenaline and 3-methoxy-4-hydroxyphenylglycol (MHPG) were also determined in the amygdaloid cortex and mid-brain regions of the sham-operated and lesioned rats. Only mianserin reversed the reduction in the noradrenaline concentration which occurred in the amygdaloid cortex following bulbectomy; the changes in noradrenaline or MHPG in the mid-brain were not correlated with this behavioural effect of mianserin.",

keywords = "3-Methoxy-4-hydroxyphenylgIycol, 8-Hydroxymianserin, Brain noradrenaline, Desmethylmianserin, Mianserin, Olfactory{\textquoteright} bulbectomy",

author = "Leonard, \{B. E.\} and O{\textquoteright}Connor, \{W. T.\}",

year = "1987",

doi = "10.1159/000118404",

language = "English",

volume = "18",

pages = "118--121",

journal = "Neuropsychobiology",

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T1 - The effect of chronically administered mianserin, 8-hydroxymianserin and desmethylmianserin on the ‘open field’ behaviour and brain noradrenaline metabolism in the olfactory bulbectomized rat

AU - Leonard, B. E.

AU - O’Connor, W. T.

PY - 1987

Y1 - 1987

N2 - The chronic effects of mianserin and two of its major metabolites on the behaviour of olfactory bulbectomized rats in the ‘open field’ apparatus were studied. When these compounds were tested at the same dose, only the parent compound was active in attenuating the hypermotility which the bulbectomized rat exhibited under these experimental conditions. Changes in the concentrations of noradrenaline and 3-methoxy-4-hydroxyphenylglycol (MHPG) were also determined in the amygdaloid cortex and mid-brain regions of the sham-operated and lesioned rats. Only mianserin reversed the reduction in the noradrenaline concentration which occurred in the amygdaloid cortex following bulbectomy; the changes in noradrenaline or MHPG in the mid-brain were not correlated with this behavioural effect of mianserin.

AB - The chronic effects of mianserin and two of its major metabolites on the behaviour of olfactory bulbectomized rats in the ‘open field’ apparatus were studied. When these compounds were tested at the same dose, only the parent compound was active in attenuating the hypermotility which the bulbectomized rat exhibited under these experimental conditions. Changes in the concentrations of noradrenaline and 3-methoxy-4-hydroxyphenylglycol (MHPG) were also determined in the amygdaloid cortex and mid-brain regions of the sham-operated and lesioned rats. Only mianserin reversed the reduction in the noradrenaline concentration which occurred in the amygdaloid cortex following bulbectomy; the changes in noradrenaline or MHPG in the mid-brain were not correlated with this behavioural effect of mianserin.

KW - 3-Methoxy-4-hydroxyphenylgIycol

KW - 8-Hydroxymianserin

KW - Brain noradrenaline

KW - Desmethylmianserin

KW - Mianserin

KW - Olfactory’ bulbectomy

UR - https://www.scopus.com/pages/publications/0023613913

U2 - 10.1159/000118404

DO - 10.1159/000118404

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AN - SCOPUS:0023613913

SN - 0302-282X

VL - 18

SP - 118

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JO - Neuropsychobiology

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IS - 3

ER -

The effect of chronically administered mianserin, 8-hydroxymianserin and desmethylmianserin on the ‘open field’ behaviour and brain noradrenaline metabolism in the olfactory bulbectomized rat

Abstract

Keywords

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