TY - JOUR
T1 - The effect of the plasma n-3/n-6 polyunsaturated fatty acid ratio on the dietary LDL phenotype transformation - Insights from the LIPGENE study
AU - Hartwich, Jadwiga
AU - Malec, Malgorzata Malczewska
AU - Partyka, Lukasz
AU - Pérez-Martinez, Pablo
AU - Marin, Carmen
AU - López-Miranda, Jose
AU - Tierney, Audrey C.
AU - Monagle, Jolene Mc
AU - Roche, Helen M.
AU - Defoort, Catherine
AU - Wolkow, Pawel
AU - Dembinska-Kieć, Aldona
PY - 2009/10
Y1 - 2009/10
N2 - Background & aims: LDL phenotype B is associated with obesity, insulin resistance, hypertriglyceridemia and oxidative stress. The effect of plasma n-3/n-6 PUFA ratio on LDL phenotype transformation was investigated. Methods: Patients with metabolic syndrome (n = 99) received one of four isocaloric diets: (A) High-fat (38% energy) SFA-rich diet (HSFA); (B) High-fat (38% energy), MUFA-rich diet (HMUFA); (C), low-fat (LF) (28% energy), high-complex carbohydrate diet with 1.24 g/d oleic sunflower oil (LFHCC) and (D): low-fat (28% energy), high-complex carbohydrate diet, with 1.24 g/d LC n-3 PUFA (LFHCC n-3) for 12 weeks. Analysis of plasma lipid profile and LDL phenotype was done pre- and post-interventions. Results: Post-dietary change of LDL density was a main effect observed in all groups. LFHCC n-3 and HFMUFA diets resulted in favorable alteration of LDL phenotype from B to A and decreased LDL density. In contrast, increased LDL density was observed in HSFA and LFHCC groups. The plasma pre-n3/n6 PUFA, Apo E change and pre-Apo CIII/CII ratios explained in 65% the post-dietary change of LDL density in diet LFHCC n-3 consumers. Conclusions: Study demonstrates efficacy of dietary n-3 PUFA to modify pro-atherogenic to less atherogenic LDL phenotype in patients with metabolic syndrome. Study identifier at ClinicalTrials.gov was NCT00429195.
AB - Background & aims: LDL phenotype B is associated with obesity, insulin resistance, hypertriglyceridemia and oxidative stress. The effect of plasma n-3/n-6 PUFA ratio on LDL phenotype transformation was investigated. Methods: Patients with metabolic syndrome (n = 99) received one of four isocaloric diets: (A) High-fat (38% energy) SFA-rich diet (HSFA); (B) High-fat (38% energy), MUFA-rich diet (HMUFA); (C), low-fat (LF) (28% energy), high-complex carbohydrate diet with 1.24 g/d oleic sunflower oil (LFHCC) and (D): low-fat (28% energy), high-complex carbohydrate diet, with 1.24 g/d LC n-3 PUFA (LFHCC n-3) for 12 weeks. Analysis of plasma lipid profile and LDL phenotype was done pre- and post-interventions. Results: Post-dietary change of LDL density was a main effect observed in all groups. LFHCC n-3 and HFMUFA diets resulted in favorable alteration of LDL phenotype from B to A and decreased LDL density. In contrast, increased LDL density was observed in HSFA and LFHCC groups. The plasma pre-n3/n6 PUFA, Apo E change and pre-Apo CIII/CII ratios explained in 65% the post-dietary change of LDL density in diet LFHCC n-3 consumers. Conclusions: Study demonstrates efficacy of dietary n-3 PUFA to modify pro-atherogenic to less atherogenic LDL phenotype in patients with metabolic syndrome. Study identifier at ClinicalTrials.gov was NCT00429195.
KW - Dietary intervention
KW - LDL phenotype
KW - n3/n6 Polyunsaturated fatty acid ratio
UR - http://www.scopus.com/inward/record.url?scp=70349808401&partnerID=8YFLogxK
U2 - 10.1016/j.clnu.2009.04.016
DO - 10.1016/j.clnu.2009.04.016
M3 - Article
C2 - 19481310
AN - SCOPUS:70349808401
SN - 0261-5614
VL - 28
SP - 510
EP - 515
JO - Clinical Nutrition
JF - Clinical Nutrition
IS - 5
ER -