TY - JOUR
T1 - The Epstein-Barr virus and the pathogenesis of lymphoma
AU - Vockerodt, Martina
AU - Yap, Lee Fah
AU - Shannon-Lowe, Claire
AU - Curley, Helen
AU - Wei, Wenbin
AU - Vrzalikova, Katerina
AU - Murray, Paul G.
N1 - Publisher Copyright:
Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Since the discovery in 1964 of the Epstein-Barr virus (EBV) in African Burkitt lymphoma, this virus has been associated with a remarkably diverse range of cancer types. Because EBV persists in the B cells of the asymptomatic host, it can easily be envisaged how it contributes to the development of B-cell lymphomas. However, EBV is also found in other cancers, including T-cell/natural killer cell lymphomas and several epithelial malignancies. Explaining the aetiological role of EBV is challenging, partly because the virus probably contributes differently to each tumour and partly because the available disease models cannot adequately recapitulate the subtle variations in the virus-host balance that exist between the different EBV-associated cancers. A further challenge is to identify the co-factors involved; because most persistently infected individuals will never develop an EBV-associated cancer, the virus cannot be working alone. This article will review what is known about the contribution of EBV to lymphoma development.
AB - Since the discovery in 1964 of the Epstein-Barr virus (EBV) in African Burkitt lymphoma, this virus has been associated with a remarkably diverse range of cancer types. Because EBV persists in the B cells of the asymptomatic host, it can easily be envisaged how it contributes to the development of B-cell lymphomas. However, EBV is also found in other cancers, including T-cell/natural killer cell lymphomas and several epithelial malignancies. Explaining the aetiological role of EBV is challenging, partly because the virus probably contributes differently to each tumour and partly because the available disease models cannot adequately recapitulate the subtle variations in the virus-host balance that exist between the different EBV-associated cancers. A further challenge is to identify the co-factors involved; because most persistently infected individuals will never develop an EBV-associated cancer, the virus cannot be working alone. This article will review what is known about the contribution of EBV to lymphoma development.
KW - Burkitt lymphoma
KW - Diffuse large B-cell lymphoma
KW - Epstein-Barr virus
KW - Hodgkin lymphoma
UR - http://www.scopus.com/inward/record.url?scp=84917705518&partnerID=8YFLogxK
U2 - 10.1002/path.4459
DO - 10.1002/path.4459
M3 - Article
C2 - 25294567
AN - SCOPUS:84917705518
SN - 0022-3417
VL - 235
SP - 312
EP - 322
JO - The Journal of Pathology
JF - The Journal of Pathology
IS - 2
ER -