The gamma-hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin

J. Cooney; Z. Kienle; T. J. Foster; P. W. O'Toole

The gamma-hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin

J. Cooney, Z. Kienle, T. J. Foster, P. W. O'Toole

University of Victoria BC

Research output: Contribution to journal › Comment/debate

Abstract

The Staphylococcus aureus gamma-hemolysin comprises two polypeptides, whereas the gamma-hemolysin locus (hlg) contains three open reading frames. The hlgA and hlgB genes encode the γ1 and γ2 components, respectively. The HlgB protein (γ2) has 27% residue identity with S. aureus alpha-toxin. Surprisingly, hlgB and hlgC are 98.5 and 99.1% identical to the lukF and lukS genes, respectively, encoding the F and S components of the Panton-Valentine leukocidin.

Original language	English
Pages (from-to)	768-771
Number of pages	4
Journal	Infection and Immunity
Volume	61
Issue number	2
Publication status	Published - 1993
Externally published	Yes

Cite this

@article{a1441897e8c2456a80a9c26ed92d0acd,

title = "The gamma-hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin",

abstract = "The Staphylococcus aureus gamma-hemolysin comprises two polypeptides, whereas the gamma-hemolysin locus (hlg) contains three open reading frames. The hlgA and hlgB genes encode the γ1 and γ2 components, respectively. The HlgB protein (γ2) has 27\% residue identity with S. aureus alpha-toxin. Surprisingly, hlgB and hlgC are 98.5 and 99.1\% identical to the lukF and lukS genes, respectively, encoding the F and S components of the Panton-Valentine leukocidin.",

author = "J. Cooney and Z. Kienle and Foster, \{T. J.\} and O'Toole, \{P. W.\}",

year = "1993",

language = "English",

volume = "61",

pages = "768--771",

journal = "Infection and Immunity",

issn = "0019-9567",

number = "2",

}

TY - JOUR

T1 - The gamma-hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin

AU - Cooney, J.

AU - Kienle, Z.

AU - Foster, T. J.

AU - O'Toole, P. W.

PY - 1993

Y1 - 1993

N2 - The Staphylococcus aureus gamma-hemolysin comprises two polypeptides, whereas the gamma-hemolysin locus (hlg) contains three open reading frames. The hlgA and hlgB genes encode the γ1 and γ2 components, respectively. The HlgB protein (γ2) has 27% residue identity with S. aureus alpha-toxin. Surprisingly, hlgB and hlgC are 98.5 and 99.1% identical to the lukF and lukS genes, respectively, encoding the F and S components of the Panton-Valentine leukocidin.

AB - The Staphylococcus aureus gamma-hemolysin comprises two polypeptides, whereas the gamma-hemolysin locus (hlg) contains three open reading frames. The hlgA and hlgB genes encode the γ1 and γ2 components, respectively. The HlgB protein (γ2) has 27% residue identity with S. aureus alpha-toxin. Surprisingly, hlgB and hlgC are 98.5 and 99.1% identical to the lukF and lukS genes, respectively, encoding the F and S components of the Panton-Valentine leukocidin.

UR - https://www.scopus.com/pages/publications/0027459158

M3 - Comment/debate

C2 - 8423103

AN - SCOPUS:0027459158

SN - 0019-9567

VL - 61

SP - 768

EP - 771

JO - Infection and Immunity

JF - Infection and Immunity

IS - 2

ER -

The gamma-hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin

Abstract

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