TY - JOUR
T1 - The impact of a short course of three lipid lowering drugs on fat oxidation during exercise in healthy volunteers
AU - Head, A.
AU - Jakeman, P. M.
AU - Kendall, M. J.
AU - Cramb, R.
AU - Maxwell, S.
PY - 1993
Y1 - 1993
N2 - We examined the impact of three lipid lowering drugs on fat oxidation during a 120 minute treadmill walk, at an exercise intensity of 50% maximal oxygen uptake (Vo2 max). Subjects (N = 24) were healthy male volunteers with normal serum chemistry, assigned to three groups (n = 8). Group A received simvastatin 20 mg twice daily, Group B received gemfibrozil 600 mg twice daily, Group C received acipimox 600 mg twice daily. Each subject performed two 120 minute walks, once with drug, and once with placebo (4 days treatment plus a final dose on the morning of the exercise trial). Treatment order was reversed for half of each group. Compared to placebo, simvastatin treatment, had no impact on fat oxidation (40.9 ± 8.6% vs 40.9 ± 9.7%), or on plasma concentration of free fatty acids (FFA), glycerol or glucose. Treatment with gemfibrozil, showed lower fat oxidation (32.3 ± 13.9% vs 39.7 ± 7.9%), and lower plasma concentrations of FFA and glycerol, but differences did not reach significance at the 0.05 level. Acipimox treatment, produced significantly lower fat oxidation (36.9 ± 12.8% vs 50.2 ± 16.1%, P = 0.011), and lower plasma concentrations of FFA and glycerol (P = <0.0001 and P = <0.0001, respectively). Plasma glucose showed a trend toward lower values with acipimox (P = 0.088). These data demonstrate that selective lipid lowering drugs can reduce fat availability for exercise metabolism, placing increased demands on carbohydrates which may reduce exercise tolerance.
AB - We examined the impact of three lipid lowering drugs on fat oxidation during a 120 minute treadmill walk, at an exercise intensity of 50% maximal oxygen uptake (Vo2 max). Subjects (N = 24) were healthy male volunteers with normal serum chemistry, assigned to three groups (n = 8). Group A received simvastatin 20 mg twice daily, Group B received gemfibrozil 600 mg twice daily, Group C received acipimox 600 mg twice daily. Each subject performed two 120 minute walks, once with drug, and once with placebo (4 days treatment plus a final dose on the morning of the exercise trial). Treatment order was reversed for half of each group. Compared to placebo, simvastatin treatment, had no impact on fat oxidation (40.9 ± 8.6% vs 40.9 ± 9.7%), or on plasma concentration of free fatty acids (FFA), glycerol or glucose. Treatment with gemfibrozil, showed lower fat oxidation (32.3 ± 13.9% vs 39.7 ± 7.9%), and lower plasma concentrations of FFA and glycerol, but differences did not reach significance at the 0.05 level. Acipimox treatment, produced significantly lower fat oxidation (36.9 ± 12.8% vs 50.2 ± 16.1%, P = 0.011), and lower plasma concentrations of FFA and glycerol (P = <0.0001 and P = <0.0001, respectively). Plasma glucose showed a trend toward lower values with acipimox (P = 0.088). These data demonstrate that selective lipid lowering drugs can reduce fat availability for exercise metabolism, placing increased demands on carbohydrates which may reduce exercise tolerance.
UR - http://www.scopus.com/inward/record.url?scp=0027450243&partnerID=8YFLogxK
U2 - 10.1136/pgmj.69.809.197
DO - 10.1136/pgmj.69.809.197
M3 - Article
C2 - 8497434
AN - SCOPUS:0027450243
SN - 0032-5473
VL - 69
SP - 197
EP - 203
JO - Postgraduate Medical Journal
JF - Postgraduate Medical Journal
IS - 809
ER -