The impact of varying dextran oxidation levels on the inhibitory activity of a bacteriocin loaded injectable hydrogel

James Flynn, Mario Culebras, Maurice N. Collins, Sarah P. Hudson

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: In the design of injectable antimicrobial dextran-alginate hydrogels, the impact of dextran oxidation and its subsequent changes in molecular weight and the incorporation of glycol chitosan on (i) gel mechanical strength and (ii) the inhibitory profile of an encapsulated bacteriocin, nisin A, are explored. As the degree of oxidation increases, the weight average molecular mass of the dextran decreases, resulting in a reduction in elastic modulus of the gels made. Upon encapsulation of the bacteriocin nisin into the gels, varying the dextran mass/oxidation level allowed the antimicrobial activity against S. aureus to be controlled. Gels made with a higher molecular weight (less oxidised) dextran show a higher initial degree of inhibition while those made with a lower molecular weight (more oxidised) dextran exhibit a more sustained inhibition. Incorporating glycol chitosan into gels composed of dextran with higher masses significantly increased their storage modulus and the gels’ initial degree of inhibition. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)308-319
Number of pages12
JournalDrug Delivery and Translational Research
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2023

Keywords

  • Antimicrobial
  • Bacteriocins
  • Controlled release
  • Drug delivery
  • Hydrogel
  • Polysaccharides

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