TY - JOUR
T1 - The innate immunity in alzheimer disease-relevance to pathogenesis and therapy
AU - Blach-Olszewska, Zofia
AU - Zaczynska, Ewa
AU - Gustaw-Rothenberg, Kasia
AU - Avila-Rodrigues, Marco
AU - Barreto, George E.
AU - Leszek, Jerzy
AU - Aliev, Gjumrakch
N1 - Publisher Copyright:
© 2015 Bentham Science Publishers.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - The genetic, cellular, and molecular changes associated with Alzheimer disease provide evidence of immune and inflammatory processes involvement in its pathogenesis. These are supported by epidemiological studies, which show some benefit of long-term use of NSAID. The hypothesis that AD is in fact an immunologically mediated and even inflammatory pathological process may be in fact scientifically intriguing. There are several obstacles that suggest the need for more complex view, in the process of targeting inflammation and immunity in AD. In our previous studies we proposed a reliable methodology to assess innate immunity in Alzheimer patients and controls. The methodology is based on the phenomenon of human leukocytes being resistant to viral infection. The unspecific character of the resistance, dependent on interferons and tumor necrosis factor, and occurrence in cells ex vivo indicate that an in vivo mechanism of innate immunity may be involved. The above mentioned resistance could be estimated in a test based on peripheral blood leukocytes infection by vesicular stomachs virus.
AB - The genetic, cellular, and molecular changes associated with Alzheimer disease provide evidence of immune and inflammatory processes involvement in its pathogenesis. These are supported by epidemiological studies, which show some benefit of long-term use of NSAID. The hypothesis that AD is in fact an immunologically mediated and even inflammatory pathological process may be in fact scientifically intriguing. There are several obstacles that suggest the need for more complex view, in the process of targeting inflammation and immunity in AD. In our previous studies we proposed a reliable methodology to assess innate immunity in Alzheimer patients and controls. The methodology is based on the phenomenon of human leukocytes being resistant to viral infection. The unspecific character of the resistance, dependent on interferons and tumor necrosis factor, and occurrence in cells ex vivo indicate that an in vivo mechanism of innate immunity may be involved. The above mentioned resistance could be estimated in a test based on peripheral blood leukocytes infection by vesicular stomachs virus.
KW - Alzheimer disease
KW - Human peripheral blood leukocytes
KW - Innate immunity
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=84940903691&partnerID=8YFLogxK
U2 - 10.2174/1381612821666150710144829
DO - 10.2174/1381612821666150710144829
M3 - Article
C2 - 26166611
AN - SCOPUS:84940903691
SN - 1381-6128
VL - 21
SP - 3582
EP - 3588
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 25
ER -