The Meniscus in Normal and Osteoarthritic Tissues: Facing the Structure Property Challenges and Current Treatment Trends

Caroline A. Murphy, Atul K. Garg, Joana Silva-Correia, Rui L. Reis, Joaquim M. Oliveira, Maurice N. Collins

Research output: Contribution to journalReview articlepeer-review

Abstract

The treatment of meniscus injuries has recently been facing a paradigm shift toward the field of tissue engineering, with the aim of regenerating damaged and diseased menisci as opposed to current treatment techniques. This review focuses on the structure and mechanics associated with the meniscus. The meniscus is defined in terms of its biological structure and composition. Biomechanics of the meniscus are discussed in detail, as an understanding of the mechanics is fundamental for the development of new meniscal treatment strategies. Key meniscal characteristics such as biological function, damage (tears), and disease are critically analyzed. The latest technologies behind meniscal repair and regeneration are assessed.

Original languageEnglish
Pages (from-to)495-521
Number of pages27
JournalAnnual Review of Biomedical Engineering
Volume21
DOIs
Publication statusPublished - 2019

Keywords

  • biomechanics
  • cartilage
  • meniscus
  • osteoarthritis
  • repair

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