The mesentery in Crohn's disease: Friend or foe?

John Calvin Coffey; Donal Peter O'Leary; Miranda G. Kiernan; Peter Faul

doi:10.1097/MOG.0000000000000280

The mesentery in Crohn's disease: Friend or foe?

John Calvin Coffey, Donal Peter O'Leary, Miranda G. Kiernan, Peter Faul

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of review This article assesses the role of the mesentery in Crohn's disease. Recent findings The mesentery is centrally positioned both anatomically and physiologically. Overlapping mesenteric and submucosal mesenchymal contributions are important in the pathobiology of Crohn's disease. Mesenteric contributions explain the topographic distribution of Crohn's disease in general and mucosal disease in particular. Operative strategies that are mesenteric based (i.e. mesocolic excision) may reduce rates of postoperative recurrence. Summary The net effect of mesenteric events in Crohn's disease is pathologic. This can be targeted by operative means. Video abstract http://links.lww.com/COG/A18.

Original language	English
Pages (from-to)	267-273
Number of pages	7
Journal	Current Opinion in Gastroenterology
Volume	32
Issue number	4
DOIs	https://doi.org/10.1097/MOG.0000000000000280
Publication status	Published - 1 Jul 2016

Keywords

Crohn's disease
mesentery
mesocolic excision
submucosa

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/MOG.0000000000000280

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title = "The mesentery in Crohn's disease: Friend or foe?",

abstract = "Purpose of review This article assesses the role of the mesentery in Crohn's disease. Recent findings The mesentery is centrally positioned both anatomically and physiologically. Overlapping mesenteric and submucosal mesenchymal contributions are important in the pathobiology of Crohn's disease. Mesenteric contributions explain the topographic distribution of Crohn's disease in general and mucosal disease in particular. Operative strategies that are mesenteric based (i.e. mesocolic excision) may reduce rates of postoperative recurrence. Summary The net effect of mesenteric events in Crohn's disease is pathologic. This can be targeted by operative means. Video abstract http://links.lww.com/COG/A18.",

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T1 - The mesentery in Crohn's disease

T2 - Friend or foe?

AU - Coffey, John Calvin

AU - O'Leary, Donal Peter

AU - Kiernan, Miranda G.

AU - Faul, Peter

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Purpose of review This article assesses the role of the mesentery in Crohn's disease. Recent findings The mesentery is centrally positioned both anatomically and physiologically. Overlapping mesenteric and submucosal mesenchymal contributions are important in the pathobiology of Crohn's disease. Mesenteric contributions explain the topographic distribution of Crohn's disease in general and mucosal disease in particular. Operative strategies that are mesenteric based (i.e. mesocolic excision) may reduce rates of postoperative recurrence. Summary The net effect of mesenteric events in Crohn's disease is pathologic. This can be targeted by operative means. Video abstract http://links.lww.com/COG/A18.

AB - Purpose of review This article assesses the role of the mesentery in Crohn's disease. Recent findings The mesentery is centrally positioned both anatomically and physiologically. Overlapping mesenteric and submucosal mesenchymal contributions are important in the pathobiology of Crohn's disease. Mesenteric contributions explain the topographic distribution of Crohn's disease in general and mucosal disease in particular. Operative strategies that are mesenteric based (i.e. mesocolic excision) may reduce rates of postoperative recurrence. Summary The net effect of mesenteric events in Crohn's disease is pathologic. This can be targeted by operative means. Video abstract http://links.lww.com/COG/A18.

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KW - mesentery

KW - mesocolic excision

KW - submucosa

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The mesentery in Crohn's disease: Friend or foe?

Abstract

Keywords

UN SDGs

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