The role of cellular flice inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer

Amanda Dutton; Lawrence S. Young; Paul G. Murray

doi:10.1517/14728222.10.1.27

The role of cellular flice inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer

Amanda Dutton, Lawrence S. Young, Paul G. Murray

University of Birmingham

Research output: Contribution to journal › Review article › peer-review

Abstract

Protection from death receptor (DR)-mediated apoptosis has been proposed as an important step in the development of malignancy, enabling tumour cells not only to survive and escape antitumour immune responses, but also to develop resistance to chemotherapy or other cancer treatments. An important regulator of DR-induced death is the cellular FADD-like IL-1β-converting enzyme inhibitory protein (c-FLIP) which, when overexpressed, can protect tumour cells from apoptosis. This review focuses on the role of c-FLIP as a tumour progression factor, with particular emphasis on recent work from the authors' laboratory concerning the contribution of c-FLIP to the pathogenesis of Hodgkin's lymphoma. The possibility of targeting c-FLIP as an approach to the treatment of cancer and, in particular, Hodgkin's lymphoma is discussed.

Original language	English
Pages (from-to)	27-35
Number of pages	9
Journal	Expert Opinion on Therapeutic Targets
Volume	10
Issue number	1
DOIs	https://doi.org/10.1517/14728222.10.1.27
Publication status	Published - Feb 2006
Externally published	Yes

Keywords

Cellular flice inhibitory protein (c-FLIP)
Gene therapy
Hodgkin's lymphoma (HL)
RNA interference

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1517/14728222.10.1.27

Cite this

@article{863cc058f053414aa5ca08cd487cf002,

title = "The role of cellular flice inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer",

abstract = "Protection from death receptor (DR)-mediated apoptosis has been proposed as an important step in the development of malignancy, enabling tumour cells not only to survive and escape antitumour immune responses, but also to develop resistance to chemotherapy or other cancer treatments. An important regulator of DR-induced death is the cellular FADD-like IL-1β-converting enzyme inhibitory protein (c-FLIP) which, when overexpressed, can protect tumour cells from apoptosis. This review focuses on the role of c-FLIP as a tumour progression factor, with particular emphasis on recent work from the authors' laboratory concerning the contribution of c-FLIP to the pathogenesis of Hodgkin's lymphoma. The possibility of targeting c-FLIP as an approach to the treatment of cancer and, in particular, Hodgkin's lymphoma is discussed.",

keywords = "Cellular flice inhibitory protein (c-FLIP), Gene therapy, Hodgkin's lymphoma (HL), RNA interference",

author = "Amanda Dutton and Young, {Lawrence S.} and Murray, {Paul G.}",

year = "2006",

month = feb,

doi = "10.1517/14728222.10.1.27",

language = "English",

volume = "10",

pages = "27--35",

journal = "Expert Opinion on Therapeutic Targets",

issn = "1472-8222",

number = "1",

}

TY - JOUR

T1 - The role of cellular flice inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer

AU - Dutton, Amanda

AU - Young, Lawrence S.

AU - Murray, Paul G.

PY - 2006/2

Y1 - 2006/2

N2 - Protection from death receptor (DR)-mediated apoptosis has been proposed as an important step in the development of malignancy, enabling tumour cells not only to survive and escape antitumour immune responses, but also to develop resistance to chemotherapy or other cancer treatments. An important regulator of DR-induced death is the cellular FADD-like IL-1β-converting enzyme inhibitory protein (c-FLIP) which, when overexpressed, can protect tumour cells from apoptosis. This review focuses on the role of c-FLIP as a tumour progression factor, with particular emphasis on recent work from the authors' laboratory concerning the contribution of c-FLIP to the pathogenesis of Hodgkin's lymphoma. The possibility of targeting c-FLIP as an approach to the treatment of cancer and, in particular, Hodgkin's lymphoma is discussed.

AB - Protection from death receptor (DR)-mediated apoptosis has been proposed as an important step in the development of malignancy, enabling tumour cells not only to survive and escape antitumour immune responses, but also to develop resistance to chemotherapy or other cancer treatments. An important regulator of DR-induced death is the cellular FADD-like IL-1β-converting enzyme inhibitory protein (c-FLIP) which, when overexpressed, can protect tumour cells from apoptosis. This review focuses on the role of c-FLIP as a tumour progression factor, with particular emphasis on recent work from the authors' laboratory concerning the contribution of c-FLIP to the pathogenesis of Hodgkin's lymphoma. The possibility of targeting c-FLIP as an approach to the treatment of cancer and, in particular, Hodgkin's lymphoma is discussed.

KW - Cellular flice inhibitory protein (c-FLIP)

KW - Gene therapy

KW - Hodgkin's lymphoma (HL)

KW - RNA interference

UR - http://www.scopus.com/inward/record.url?scp=33144481343&partnerID=8YFLogxK

U2 - 10.1517/14728222.10.1.27

DO - 10.1517/14728222.10.1.27

M3 - Review article

C2 - 16441226

AN - SCOPUS:33144481343

SN - 1472-8222

VL - 10

SP - 27

EP - 35

JO - Expert Opinion on Therapeutic Targets

JF - Expert Opinion on Therapeutic Targets

IS - 1

ER -

The role of cellular flice inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this